Imaging biomarkers of epileptogenecity after traumatic brain injury – Preclinical frontiers

Riikka Immonen, Neil G. Harris, David Wright, Leigh Johnston, Eppu Manninen, Gregory Smith, Afshin Paydar, Craig A. Branch, Olli Grohn

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Posttraumatic epilepsy (PTE) is a major neurodegenerative disease accounting for 20% of symptomatic epilepsy cases. A long latent phase offers a potential window for prophylactic treatment strategies to prevent epilepsy onset, provided that the patients at risk can be identified. Some promising imaging biomarker candidates for posttraumatic epileptogenesis have been identified, but more are required to provide the specificity and sensitivity for accurate prediction. Experimental models and preclinical longitudinal, multimodal imaging studies allow follow-up of complex cascade of events initiated by traumatic brain injury, as well as monitoring of treatment effects. Preclinical imaging data from the posttraumatic brain are rich in information, yet examination of their specific relevance to epilepsy is lacking. Accumulating evidence from ongoing preclinical studies in TBI support insight into processes involved in epileptogenesis, e.g. inflammation and changes in functional and structural brain-wide connectivity. These efforts are likely to produce both new biomarkers and treatment targets for PTE.

Original languageEnglish (US)
JournalNeurobiology of Disease
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Epilepsy
Biomarkers
Multimodal Imaging
Brain
Neurodegenerative Diseases
Theoretical Models
Therapeutics
Traumatic Brain Injury
Inflammation
Sensitivity and Specificity

Keywords

  • Atrophy
  • Axonal injury
  • Connectivity
  • Epileptogenesis
  • Inflammation
  • Magnetic resonance imaging (MRI)
  • Plasticity
  • Positron emission tomography (PET)
  • Vascular injury

ASJC Scopus subject areas

  • Neurology

Cite this

Immonen, R., Harris, N. G., Wright, D., Johnston, L., Manninen, E., Smith, G., ... Grohn, O. (Accepted/In press). Imaging biomarkers of epileptogenecity after traumatic brain injury – Preclinical frontiers. Neurobiology of Disease. https://doi.org/10.1016/j.nbd.2018.10.008

Imaging biomarkers of epileptogenecity after traumatic brain injury – Preclinical frontiers. / Immonen, Riikka; Harris, Neil G.; Wright, David; Johnston, Leigh; Manninen, Eppu; Smith, Gregory; Paydar, Afshin; Branch, Craig A.; Grohn, Olli.

In: Neurobiology of Disease, 01.01.2018.

Research output: Contribution to journalArticle

Immonen, Riikka ; Harris, Neil G. ; Wright, David ; Johnston, Leigh ; Manninen, Eppu ; Smith, Gregory ; Paydar, Afshin ; Branch, Craig A. ; Grohn, Olli. / Imaging biomarkers of epileptogenecity after traumatic brain injury – Preclinical frontiers. In: Neurobiology of Disease. 2018.
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