TY - JOUR
T1 - Image guidance for precise conformal radiotherapy
AU - Mackie, Thomas Rockwell
AU - Kapatoes, Jeff
AU - Ruchala, Ken
AU - Lu, Weiguo
AU - Wu, Chuan
AU - Olivera, Gustavo
AU - Forrest, Lisa
AU - Tome, Wolfgang
AU - Welsh, Jim
AU - Jeraj, Robert
AU - Harari, Paul
AU - Reckwerdt, Paul
AU - Paliwal, Bhudatt
AU - Ritter, Mark
AU - Keller, Harry
AU - Fowler, Jack
AU - Mehta, Minesh
N1 - Funding Information:
The authors acknowledge the support of NIH CA48902, NIH P01 CA088960, and TomoTherapy Inc. The authors associated with TomoTherapy Inc. have a financial interest in that company.
PY - 2003/5/1
Y1 - 2003/5/1
N2 - Purpose To review the state of the art in image-guided precision conformal radiotherapy and to describe how helical tomotherapy compares with the image-guided practices being developed for conventional radiotherapy. Methods and materials Image guidance is beginning to be the fundamental basis for radiotherapy planning, delivery, and verification. Radiotherapy planning requires more precision in the extension and localization of disease. When greater precision is not possible, conformal avoidance methodology may be indicated whereby the margin of disease extension is generous, except where sensitive normal tissues exist. Radiotherapy delivery requires better precision in the definition of treatment volume, on a daily basis if necessary. Helical tomotherapy has been designed to use CT imaging technology to plan, deliver, and verify that the delivery has been carried out as planned. The image-guided processes of helical tomotherapy that enable this goal are described. Results Examples of the results of helical tomotherapy processes for image-guided intensity-modulated radiotherapy are presented. These processes include megavoltage CT acquisition, automated segmentation of CT images, dose reconstruction using the CT image set, deformable registration of CT images, and reoptimization. Conclusion Image-guided precision conformal radiotherapy can be used as a tool to treat the tumor yet spare critical structures. Helical tomotherapy has been designed from the ground up as an integrated image-guided intensity-modulated radiotherapy system and allows new verification processes based on megavoltage CT images to be implemented.
AB - Purpose To review the state of the art in image-guided precision conformal radiotherapy and to describe how helical tomotherapy compares with the image-guided practices being developed for conventional radiotherapy. Methods and materials Image guidance is beginning to be the fundamental basis for radiotherapy planning, delivery, and verification. Radiotherapy planning requires more precision in the extension and localization of disease. When greater precision is not possible, conformal avoidance methodology may be indicated whereby the margin of disease extension is generous, except where sensitive normal tissues exist. Radiotherapy delivery requires better precision in the definition of treatment volume, on a daily basis if necessary. Helical tomotherapy has been designed to use CT imaging technology to plan, deliver, and verify that the delivery has been carried out as planned. The image-guided processes of helical tomotherapy that enable this goal are described. Results Examples of the results of helical tomotherapy processes for image-guided intensity-modulated radiotherapy are presented. These processes include megavoltage CT acquisition, automated segmentation of CT images, dose reconstruction using the CT image set, deformable registration of CT images, and reoptimization. Conclusion Image-guided precision conformal radiotherapy can be used as a tool to treat the tumor yet spare critical structures. Helical tomotherapy has been designed from the ground up as an integrated image-guided intensity-modulated radiotherapy system and allows new verification processes based on megavoltage CT images to be implemented.
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U2 - 10.1016/S0360-3016(03)00090-7
DO - 10.1016/S0360-3016(03)00090-7
M3 - Article
C2 - 12694827
AN - SCOPUS:0345701463
SN - 0360-3016
VL - 56
SP - 89
EP - 105
JO - International Journal of Radiation Oncology Biology Physics
JF - International Journal of Radiation Oncology Biology Physics
IS - 1
ER -