ILAE type 3 hippocampal sclerosis in patients with anti-GAD - Related epilepsy

Robert L. Glover, Lauren V. De Niro, Patrick A. LaSala, Karen M. Weidenheim, Jerome J. Graber, Alexis D. Boro

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: To describe the neuropathologic findings and clinical course of 2 patients who underwent temporal lobectomy for medically refractive epilepsy and were later found to have high anti-glutamic acid decarboxylase (GAD) concentrations. Methods: Small case series. Results: Neuropathologic examination of both patients revealed International League Against Epilepsy (ILAE) type 3 hippocampal sclerosis. Following surgery, both developed signs and symptoms of stiff person syndrome and later cerebellar ataxia. Laboratory studies demonstrated high concentrations of anti-GAD antibodies in both patients. Conclusions: These cases suggest that ILAE type 3 hippocampal sclerosis may be immunologically related to and may exist as part of a broader anti-GAD-related neurologic syndrome in some instances.

Original languageEnglish (US)
Article numbere122
JournalNeurology: Neuroimmunology and NeuroInflammation
Volume2
Issue number4
DOIs
StatePublished - 2015

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Glutamate Decarboxylase
Sclerosis
Epilepsy
Stiff-Person Syndrome
Cerebellar Ataxia
Nervous System
Signs and Symptoms
Antibodies

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

ILAE type 3 hippocampal sclerosis in patients with anti-GAD - Related epilepsy. / Glover, Robert L.; De Niro, Lauren V.; LaSala, Patrick A.; Weidenheim, Karen M.; Graber, Jerome J.; Boro, Alexis D.

In: Neurology: Neuroimmunology and NeuroInflammation, Vol. 2, No. 4, e122, 2015.

Research output: Contribution to journalArticle

Glover, Robert L. ; De Niro, Lauren V. ; LaSala, Patrick A. ; Weidenheim, Karen M. ; Graber, Jerome J. ; Boro, Alexis D. / ILAE type 3 hippocampal sclerosis in patients with anti-GAD - Related epilepsy. In: Neurology: Neuroimmunology and NeuroInflammation. 2015 ; Vol. 2, No. 4.
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