ILAE Official Report: A practical clinical definition of epilepsy

Robert S. Fisher, Carlos Acevedo, Alexis Arzimanoglou, Alicia Bogacz, J. Helen Cross, Christian E. Elger, Jerome Engel, Lars Forsgren, Jacqueline A. French, Mike Glynn, Dale C. Hesdorffer, B. I. Lee, Gary W. Mathern, Solomon L. Moshe, Emilio Perucca, Ingrid E. Scheffer, Torbjörn Tomson, Masako Watanabe, Samuel Wiebe

Research output: Contribution to journalArticle

1359 Citations (Scopus)

Abstract

Epilepsy was defined conceptually in 2005 as a disorder of the brain characterized by an enduring predisposition to generate epileptic seizures. This definition is usually practically applied as having two unprovoked seizures >24 h apart. The International League Against Epilepsy (ILAE) accepted recommendations of a task force altering the practical definition for special circumstances that do not meet the two unprovoked seizures criteria. The task force proposed that epilepsy be considered to be a disease of the brain defined by any of the following conditions: (1) At least two unprovoked (or reflex) seizures occurring >24 h apart; (2) one unprovoked (or reflex) seizure and a probability of further seizures similar to the general recurrence risk (at least 60%) after two unprovoked seizures, occurring over the next 10 years; (3) diagnosis of an epilepsy syndrome. Epilepsy is considered to be resolved for individuals who either had an age-dependent epilepsy syndrome but are now past the applicable age or who have remained seizure-free for the last 10 years and off antiseizure medicines for at least the last 5 years. "Resolved" is not necessarily identical to the conventional view of "remission or "cure." Different practical definitions may be formed and used for various specific purposes. This revised definition of epilepsy brings the term in concordance with common use. A PowerPoint slide summarizing this article is available for download in the Supporting Information section here.

Original languageEnglish (US)
Pages (from-to)475-482
Number of pages8
JournalEpilepsia
Volume55
Issue number4
DOIs
StatePublished - 2014

Fingerprint

Epilepsy
Seizures
Brain Diseases
Advisory Committees
Reflex
Recurrence

Keywords

  • Definition
  • Epilepsy
  • Recurrence
  • Seizure
  • Unprovoked

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)

Cite this

Fisher, R. S., Acevedo, C., Arzimanoglou, A., Bogacz, A., Cross, J. H., Elger, C. E., ... Wiebe, S. (2014). ILAE Official Report: A practical clinical definition of epilepsy. Epilepsia, 55(4), 475-482. https://doi.org/10.1111/epi.12550

ILAE Official Report : A practical clinical definition of epilepsy. / Fisher, Robert S.; Acevedo, Carlos; Arzimanoglou, Alexis; Bogacz, Alicia; Cross, J. Helen; Elger, Christian E.; Engel, Jerome; Forsgren, Lars; French, Jacqueline A.; Glynn, Mike; Hesdorffer, Dale C.; Lee, B. I.; Mathern, Gary W.; Moshe, Solomon L.; Perucca, Emilio; Scheffer, Ingrid E.; Tomson, Torbjörn; Watanabe, Masako; Wiebe, Samuel.

In: Epilepsia, Vol. 55, No. 4, 2014, p. 475-482.

Research output: Contribution to journalArticle

Fisher, RS, Acevedo, C, Arzimanoglou, A, Bogacz, A, Cross, JH, Elger, CE, Engel, J, Forsgren, L, French, JA, Glynn, M, Hesdorffer, DC, Lee, BI, Mathern, GW, Moshe, SL, Perucca, E, Scheffer, IE, Tomson, T, Watanabe, M & Wiebe, S 2014, 'ILAE Official Report: A practical clinical definition of epilepsy', Epilepsia, vol. 55, no. 4, pp. 475-482. https://doi.org/10.1111/epi.12550
Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE et al. ILAE Official Report: A practical clinical definition of epilepsy. Epilepsia. 2014;55(4):475-482. https://doi.org/10.1111/epi.12550
Fisher, Robert S. ; Acevedo, Carlos ; Arzimanoglou, Alexis ; Bogacz, Alicia ; Cross, J. Helen ; Elger, Christian E. ; Engel, Jerome ; Forsgren, Lars ; French, Jacqueline A. ; Glynn, Mike ; Hesdorffer, Dale C. ; Lee, B. I. ; Mathern, Gary W. ; Moshe, Solomon L. ; Perucca, Emilio ; Scheffer, Ingrid E. ; Tomson, Torbjörn ; Watanabe, Masako ; Wiebe, Samuel. / ILAE Official Report : A practical clinical definition of epilepsy. In: Epilepsia. 2014 ; Vol. 55, No. 4. pp. 475-482.
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