IL10 and TNF variants and risk of non-Hodgkin lymphoma among three Asian populations

Howard D. Hosgood, Wing Yan Au, Hee Nam Kim, Jie Liu, Wei Hu, Jovic Tse, Bao Song, Kit Fai Wong, Je Jung Lee, Stephen J. Chanock, L. P. Siu, Mark P. Purdue, Min Ho Shin, Jinming Yu, Raymond Liang, Hyeoung Joon Kim, Nathaniel Rothman, Qing Lan

Research output: Contribution to journalArticle

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Abstract

Genetic variation in immune-related genes, such as IL10 and TNF, have been associated with the development of non-Hodgkin lymphoma (NHL) in Caucasian populations. To test the hypothesis that IL10 and TNF polymorphisms may be associated with NHL risk in Asian populations, we genotyped 20 single nucleotide polymorphisms (SNPs) within the IL10 and TNF/LTA loci in three independent case-control studies (2635 cases and 4234 controls). IL10 rs1800871, rs1800872, and rs1800896 were genotyped in all three studies, while 5 of the remaining SNPs were genotyped in two studies, and 12 in a single study. IL10 rs1800896 was associated with B cell lymphoma [per-allele odds ratio (OR) = 1.25, 95 % confidence interval (CI) 1.08-1.45; p trend = 0.003], specifically diffuse large B cell lymphoma (DLBCL) (per-allele OR = 1.29, 95 % CI 1.08-1.53; p trend = 0.004), as well as T cell lymphoma (per-allele OR = 1.44, 95 % CI 1.13-1.82; p trend = 0.003). TNF rs1800629, which was genotyped in only two of our studies, was also associated with B cell lymphoma (per-allele OR = 0.77, 95 % CI 0.64-0.91; p trend = 0.003), specifically DLBCL (per-allele OR = 0.69, 95 % CI 0.55-0.86; p trend = 0.001). Our findings suggest that genetic variation in IL10 and TNF may also play a role in lymphomagenesis in Asian populations.

Original languageEnglish (US)
Pages (from-to)793-799
Number of pages7
JournalInternational Journal of Hematology
Volume97
Issue number6
DOIs
StatePublished - Jun 2013

Fingerprint

Interleukin-10
Non-Hodgkin's Lymphoma
Alleles
Odds Ratio
Confidence Intervals
Population
Lymphoma, Large B-Cell, Diffuse
B-Cell Lymphoma
Single Nucleotide Polymorphism
T-Cell Lymphoma
Case-Control Studies
Genes

Keywords

  • Asia
  • DLBCL
  • IL10
  • NHL
  • Subtype
  • TNF

ASJC Scopus subject areas

  • Hematology

Cite this

IL10 and TNF variants and risk of non-Hodgkin lymphoma among three Asian populations. / Hosgood, Howard D.; Au, Wing Yan; Kim, Hee Nam; Liu, Jie; Hu, Wei; Tse, Jovic; Song, Bao; Wong, Kit Fai; Lee, Je Jung; Chanock, Stephen J.; Siu, L. P.; Purdue, Mark P.; Shin, Min Ho; Yu, Jinming; Liang, Raymond; Kim, Hyeoung Joon; Rothman, Nathaniel; Lan, Qing.

In: International Journal of Hematology, Vol. 97, No. 6, 06.2013, p. 793-799.

Research output: Contribution to journalArticle

Hosgood, HD, Au, WY, Kim, HN, Liu, J, Hu, W, Tse, J, Song, B, Wong, KF, Lee, JJ, Chanock, SJ, Siu, LP, Purdue, MP, Shin, MH, Yu, J, Liang, R, Kim, HJ, Rothman, N & Lan, Q 2013, 'IL10 and TNF variants and risk of non-Hodgkin lymphoma among three Asian populations', International Journal of Hematology, vol. 97, no. 6, pp. 793-799. https://doi.org/10.1007/s12185-013-1345-5
Hosgood, Howard D. ; Au, Wing Yan ; Kim, Hee Nam ; Liu, Jie ; Hu, Wei ; Tse, Jovic ; Song, Bao ; Wong, Kit Fai ; Lee, Je Jung ; Chanock, Stephen J. ; Siu, L. P. ; Purdue, Mark P. ; Shin, Min Ho ; Yu, Jinming ; Liang, Raymond ; Kim, Hyeoung Joon ; Rothman, Nathaniel ; Lan, Qing. / IL10 and TNF variants and risk of non-Hodgkin lymphoma among three Asian populations. In: International Journal of Hematology. 2013 ; Vol. 97, No. 6. pp. 793-799.
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