IL-16 expression in lymphocytes and microglia in HIV-1 encephalitis

M. L. Zhao, Q. Si, S. C. Lee

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

IL-16 is a natural ligand for the CD4 molecule and is known for its chemotactic and anti-HIV-1 activities. We determined IL-16 expression in human brain tissue with HIV-1 encephalitis by specific immunocytochemistry and showed that infiltrating lymphocytes and activated microglia express IL-16. IL-16 immunoreactivity was particularly pronounced in microglial nodules. In vitro, human foetal microglia and not astrocytes produce IL-16, and HIV-1 infection up-regulates microglial IL-16 release in a Nef-dependent manner. These results support the notion that, in the brain, IL-16 is a macrophage-lineage specific modulator of the inflammatory response and HIV-1 expression. Recruitment of IL-16+ T cells and microglia/ macrophages may represent an innate response to HIV-1 infection in the central nervous system that counterbalances viral stimulatory factors.

Original languageEnglish (US)
Pages (from-to)233-242
Number of pages10
JournalNeuropathology and Applied Neurobiology
Volume30
Issue number3
DOIs
StatePublished - Jun 2004

Fingerprint

Interleukin-16
Microglia
Encephalitis
HIV-1
Lymphocytes
HIV Infections
Macrophages
CD4 Antigens
Brain
Astrocytes
Up-Regulation
Central Nervous System
Immunohistochemistry
Ligands
T-Lymphocytes

Keywords

  • Astrocyte
  • Chemokine
  • Macrophage
  • Microglial nodule
  • Nef

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

IL-16 expression in lymphocytes and microglia in HIV-1 encephalitis. / Zhao, M. L.; Si, Q.; Lee, S. C.

In: Neuropathology and Applied Neurobiology, Vol. 30, No. 3, 06.2004, p. 233-242.

Research output: Contribution to journalArticle

Zhao, M. L. ; Si, Q. ; Lee, S. C. / IL-16 expression in lymphocytes and microglia in HIV-1 encephalitis. In: Neuropathology and Applied Neurobiology. 2004 ; Vol. 30, No. 3. pp. 233-242.
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