Idiopathic short stature: A clinical review

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations

Abstract

IMPORTANCE: Approximately 2% of children are defined as having short stature. Deciding when to pursue recombinant human growth hormone therapy to increase adult height is controversial. OBJECTIVE: To review the management of children with idiopathic short stature, including diagnostic evaluation and therapeutic options. EVIDENCE REVIEW: Systematic literature search of PubMed, Embase, and the Cochrane Library databases. For height outcome, articles were limited to studies reporting adult height and to systematic reviews. FINDINGS: Recombinant human growth hormone therapy of children with idiopathic short stature increases height in some children. The estimated mean gain in adult height is 5.2 cm (2 in). The cost-benefit ratio is controversial. Treatment with growth hormone appears safe in the short term, while data on long-term effects are limited because studies of long-term efficacy were not powered to determine safety. CONCLUSIONS AND RELEVANCE: Growth hormone treatment may be considered in some children with idiopathic short stature.

Original languageEnglish (US)
Pages (from-to)1787-1796
Number of pages10
JournalJAMA - Journal of the American Medical Association
Volume311
Issue number17
DOIs
StatePublished - May 7 2014
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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