Identification of serious drug-drug interactions: Results of the partnership to prevent drug-drug interactions

Daniel C. Malone, Jacob Abarca, Philip D. Hansten, Amy J. Grizzle, Edward P. Armstrong, Robin C. Van Bergen, Babette S. Duncan-Edgar, Steven L. Solomon, Richard B. Lipton

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objective: To develop a list of clinically important drug-drug interactions (DDIs) likely to be encountered in community and ambulatory pharmacy settings and detected by a computerized pharmacy system. Design: Cross-sectional, one-time evaluation. Setting: United States in fall 2001. Participants: An expert panel comprising two physicians, two clinical pharmacists, and an expert on DDIs. Interventions: Systematic review of drug interaction compendia and published literature, ratings (on a 1 to 10 scale) of various clinical aspects of DDIs (e.g., clinical importance, quality and quantity of evidence, causal relationship, risk of morbidity and mortality), and a modified Delphi consensus-building process. Main outcome measure: Panelists' opinions about clinical importance of DDIs. Results: The expert panel considered 56 DDIs. Of these, 28 had a mean clinical importance score of 8.0 or more. The ratings for clinical importance ranged from 3.2 to 9.6, with a mean ± SD of 7.5 ± 1.5 across the combinations examined. The mean score for the quality of literature suggesting the interaction exists ranged from 1.0 to 9.6, with a mean ± SD of 5.8 ± 2.5. In terms of substantiation of the interactions evaluated, the mean ± SD rating was 6.3 ± 2.2, with a range from 1.4 to 9.2. Through the modified Delphi process, the panel determined that 25 interactions were clinically important. Conclusion: Using an expert panel and a standard evaluation tool, 25 clinically important drug interactions that are likely to occur in the community and ambulatory pharmacy settings were identified. Pharmacists should take steps to prevent patients from receiving these interacting medications, and computer software vendors should focus interaction alerts on these and similarly important DDIs.

Original languageEnglish (US)
Pages (from-to)65-76
Number of pages12
JournalAmerican Journal Geriatric Pharmacotherapy
Volume3
Issue number2
DOIs
StatePublished - Jun 2005

Fingerprint

Drug Interactions
Pharmaceutical Preparations
Pharmacies
Pharmacists
Software
Outcome Assessment (Health Care)
Morbidity
Physicians
Mortality

Keywords

  • Drug utilization review
  • Drug-drug interactions
  • Medication errors
  • Patients safety

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Geriatrics and Gerontology

Cite this

Identification of serious drug-drug interactions : Results of the partnership to prevent drug-drug interactions. / Malone, Daniel C.; Abarca, Jacob; Hansten, Philip D.; Grizzle, Amy J.; Armstrong, Edward P.; Van Bergen, Robin C.; Duncan-Edgar, Babette S.; Solomon, Steven L.; Lipton, Richard B.

In: American Journal Geriatric Pharmacotherapy, Vol. 3, No. 2, 06.2005, p. 65-76.

Research output: Contribution to journalArticle

Malone, DC, Abarca, J, Hansten, PD, Grizzle, AJ, Armstrong, EP, Van Bergen, RC, Duncan-Edgar, BS, Solomon, SL & Lipton, RB 2005, 'Identification of serious drug-drug interactions: Results of the partnership to prevent drug-drug interactions', American Journal Geriatric Pharmacotherapy, vol. 3, no. 2, pp. 65-76. https://doi.org/10.1016/j.amjopharm.2005.05.001
Malone, Daniel C. ; Abarca, Jacob ; Hansten, Philip D. ; Grizzle, Amy J. ; Armstrong, Edward P. ; Van Bergen, Robin C. ; Duncan-Edgar, Babette S. ; Solomon, Steven L. ; Lipton, Richard B. / Identification of serious drug-drug interactions : Results of the partnership to prevent drug-drug interactions. In: American Journal Geriatric Pharmacotherapy. 2005 ; Vol. 3, No. 2. pp. 65-76.
@article{62cd5425258e47b6b646dba18c9f47fe,
title = "Identification of serious drug-drug interactions: Results of the partnership to prevent drug-drug interactions",
abstract = "Objective: To develop a list of clinically important drug-drug interactions (DDIs) likely to be encountered in community and ambulatory pharmacy settings and detected by a computerized pharmacy system. Design: Cross-sectional, one-time evaluation. Setting: United States in fall 2001. Participants: An expert panel comprising two physicians, two clinical pharmacists, and an expert on DDIs. Interventions: Systematic review of drug interaction compendia and published literature, ratings (on a 1 to 10 scale) of various clinical aspects of DDIs (e.g., clinical importance, quality and quantity of evidence, causal relationship, risk of morbidity and mortality), and a modified Delphi consensus-building process. Main outcome measure: Panelists' opinions about clinical importance of DDIs. Results: The expert panel considered 56 DDIs. Of these, 28 had a mean clinical importance score of 8.0 or more. The ratings for clinical importance ranged from 3.2 to 9.6, with a mean ± SD of 7.5 ± 1.5 across the combinations examined. The mean score for the quality of literature suggesting the interaction exists ranged from 1.0 to 9.6, with a mean ± SD of 5.8 ± 2.5. In terms of substantiation of the interactions evaluated, the mean ± SD rating was 6.3 ± 2.2, with a range from 1.4 to 9.2. Through the modified Delphi process, the panel determined that 25 interactions were clinically important. Conclusion: Using an expert panel and a standard evaluation tool, 25 clinically important drug interactions that are likely to occur in the community and ambulatory pharmacy settings were identified. Pharmacists should take steps to prevent patients from receiving these interacting medications, and computer software vendors should focus interaction alerts on these and similarly important DDIs.",
keywords = "Drug utilization review, Drug-drug interactions, Medication errors, Patients safety",
author = "Malone, {Daniel C.} and Jacob Abarca and Hansten, {Philip D.} and Grizzle, {Amy J.} and Armstrong, {Edward P.} and {Van Bergen}, {Robin C.} and Duncan-Edgar, {Babette S.} and Solomon, {Steven L.} and Lipton, {Richard B.}",
year = "2005",
month = "6",
doi = "10.1016/j.amjopharm.2005.05.001",
language = "English (US)",
volume = "3",
pages = "65--76",
journal = "American Journal Geriatric Pharmacotherapy",
issn = "1543-5946",
publisher = "Excerpta Medica",
number = "2",

}

TY - JOUR

T1 - Identification of serious drug-drug interactions

T2 - Results of the partnership to prevent drug-drug interactions

AU - Malone, Daniel C.

AU - Abarca, Jacob

AU - Hansten, Philip D.

AU - Grizzle, Amy J.

AU - Armstrong, Edward P.

AU - Van Bergen, Robin C.

AU - Duncan-Edgar, Babette S.

AU - Solomon, Steven L.

AU - Lipton, Richard B.

PY - 2005/6

Y1 - 2005/6

N2 - Objective: To develop a list of clinically important drug-drug interactions (DDIs) likely to be encountered in community and ambulatory pharmacy settings and detected by a computerized pharmacy system. Design: Cross-sectional, one-time evaluation. Setting: United States in fall 2001. Participants: An expert panel comprising two physicians, two clinical pharmacists, and an expert on DDIs. Interventions: Systematic review of drug interaction compendia and published literature, ratings (on a 1 to 10 scale) of various clinical aspects of DDIs (e.g., clinical importance, quality and quantity of evidence, causal relationship, risk of morbidity and mortality), and a modified Delphi consensus-building process. Main outcome measure: Panelists' opinions about clinical importance of DDIs. Results: The expert panel considered 56 DDIs. Of these, 28 had a mean clinical importance score of 8.0 or more. The ratings for clinical importance ranged from 3.2 to 9.6, with a mean ± SD of 7.5 ± 1.5 across the combinations examined. The mean score for the quality of literature suggesting the interaction exists ranged from 1.0 to 9.6, with a mean ± SD of 5.8 ± 2.5. In terms of substantiation of the interactions evaluated, the mean ± SD rating was 6.3 ± 2.2, with a range from 1.4 to 9.2. Through the modified Delphi process, the panel determined that 25 interactions were clinically important. Conclusion: Using an expert panel and a standard evaluation tool, 25 clinically important drug interactions that are likely to occur in the community and ambulatory pharmacy settings were identified. Pharmacists should take steps to prevent patients from receiving these interacting medications, and computer software vendors should focus interaction alerts on these and similarly important DDIs.

AB - Objective: To develop a list of clinically important drug-drug interactions (DDIs) likely to be encountered in community and ambulatory pharmacy settings and detected by a computerized pharmacy system. Design: Cross-sectional, one-time evaluation. Setting: United States in fall 2001. Participants: An expert panel comprising two physicians, two clinical pharmacists, and an expert on DDIs. Interventions: Systematic review of drug interaction compendia and published literature, ratings (on a 1 to 10 scale) of various clinical aspects of DDIs (e.g., clinical importance, quality and quantity of evidence, causal relationship, risk of morbidity and mortality), and a modified Delphi consensus-building process. Main outcome measure: Panelists' opinions about clinical importance of DDIs. Results: The expert panel considered 56 DDIs. Of these, 28 had a mean clinical importance score of 8.0 or more. The ratings for clinical importance ranged from 3.2 to 9.6, with a mean ± SD of 7.5 ± 1.5 across the combinations examined. The mean score for the quality of literature suggesting the interaction exists ranged from 1.0 to 9.6, with a mean ± SD of 5.8 ± 2.5. In terms of substantiation of the interactions evaluated, the mean ± SD rating was 6.3 ± 2.2, with a range from 1.4 to 9.2. Through the modified Delphi process, the panel determined that 25 interactions were clinically important. Conclusion: Using an expert panel and a standard evaluation tool, 25 clinically important drug interactions that are likely to occur in the community and ambulatory pharmacy settings were identified. Pharmacists should take steps to prevent patients from receiving these interacting medications, and computer software vendors should focus interaction alerts on these and similarly important DDIs.

KW - Drug utilization review

KW - Drug-drug interactions

KW - Medication errors

KW - Patients safety

UR - http://www.scopus.com/inward/record.url?scp=23944522513&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23944522513&partnerID=8YFLogxK

U2 - 10.1016/j.amjopharm.2005.05.001

DO - 10.1016/j.amjopharm.2005.05.001

M3 - Article

AN - SCOPUS:23944522513

VL - 3

SP - 65

EP - 76

JO - American Journal Geriatric Pharmacotherapy

JF - American Journal Geriatric Pharmacotherapy

SN - 1543-5946

IS - 2

ER -