@article{8676eb16cfe44d2c9683505f27cedaea,
title = "Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFκB activity within two separate high-throughput screens of NFκB activation",
abstract = "We describe here a series of N-(quinolin-8-yl)benzenesulfonamides capable of suppressing the NFκB pathway identified from two high-throughput screens run at two centers of the NIH Molecular Libraries Initiative. These small molecules were confirmed in both primary and secondary assays of NFκB activation and expanded upon through analogue synthesis. The series exhibited potencies in the cell-based assays at as low as 0.6 μM, and several indications suggest that the targeted activity lies within a common region of the NFκB pathway.",
keywords = "NFκB inhibitor",
author = "Yuli Xie and Deng, {Shi Xian} and Thomas, {Craig J.} and Yidong Liu and Zhang, {Ya Qin} and Alison Rinderspacher and Wenwei Huang and Gangli Gong and Michael Wyler and Efithia Cayanis and Nathalie Aulner and Udo T{\"o}bben and Caty Chung and Sergey Pampou and Noel Southall and Du{\v s}ica Vidovi{\'c} and Stephan Sch{\"u}rer and Lars Branden and Davis, {R. Eric} and Staudt, {Louis M.} and James Inglese and Austin, {Christopher P.} and Landry, {Donald W.} and Smith, {Deborah H.} and Auld, {Douglas S.}",
note = "Funding Information: The authors would like to thank Jeremy Smith, Adam Yasgar, and Paul Shinn for assistance in compound management at the NIH Chemical Genomics Center, and Darryl Leja of the National Human Genome Research Institute for graphical artwork. We thank Ms. Allison Peck for critical reading of this manuscript. This research was supported by the Molecular Libraries Initiative of the National Institutes of Health Roadmap for Medical Research and the Intramural Research Program of the National Human Genome Research Institute, National Institutes of Health.",
year = "2008",
month = jan,
day = "1",
doi = "10.1016/j.bmcl.2007.10.100",
language = "English (US)",
volume = "18",
pages = "329--335",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "1",
}