Identification of autoantibodies associated with myelin damage in multiple sclerosis

Claude P. Genain, Barbara Cannella, Stephen L. Hauser, Cedric S. Raine

Research output: Contribution to journalArticle

727 Scopus citations

Abstract

The molecular mechanisms underlying myelin sheath destruction in multiple sclerosis lesions remain unresolved. With immunogold-labeled peptides of myelin antigens and high-resolution microscopy, techniques that can detect antigen-specific antibodies in situ, we have identified autoantibodies specific for the central nervous system myelin antigen myelin/oligodendrocyte glycoprotein. These autoantibodies were specifically bound to disintegrating myelin around axons in lesions of acute multiple sclerosis and the marmoset model of allergic encephalomyelitis. These findings represent direct evidence that autoantibodies against a specific myelin protein mediate target membrane damage in central nervous system demyelinating disease.

Original languageEnglish (US)
Pages (from-to)170-175
Number of pages6
JournalNature Medicine
Volume5
Issue number2
DOIs
StatePublished - Feb 1 1999

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Genain, C. P., Cannella, B., Hauser, S. L., & Raine, C. S. (1999). Identification of autoantibodies associated with myelin damage in multiple sclerosis. Nature Medicine, 5(2), 170-175. https://doi.org/10.1038/5532