Identification of autoantibodies associated with myelin damage in multiple sclerosis

Claude P. Genain, Barbara Cannella, Stephen L. Hauser, Cedric S. Raine

Research output: Contribution to journalArticle

714 Citations (Scopus)

Abstract

The molecular mechanisms underlying myelin sheath destruction in multiple sclerosis lesions remain unresolved. With immunogold-labeled peptides of myelin antigens and high-resolution microscopy, techniques that can detect antigen-specific antibodies in situ, we have identified autoantibodies specific for the central nervous system myelin antigen myelin/oligodendrocyte glycoprotein. These autoantibodies were specifically bound to disintegrating myelin around axons in lesions of acute multiple sclerosis and the marmoset model of allergic encephalomyelitis. These findings represent direct evidence that autoantibodies against a specific myelin protein mediate target membrane damage in central nervous system demyelinating disease.

Original languageEnglish (US)
Pages (from-to)170-175
Number of pages6
JournalNature Medicine
Volume5
Issue number2
DOIs
StatePublished - Feb 1999

Fingerprint

Myelin Sheath
Autoantibodies
Multiple Sclerosis
Neurology
Antigens
Myelin-Oligodendrocyte Glycoprotein
Myelin Proteins
Callithrix
Autoimmune Experimental Encephalomyelitis
Central Nervous System Diseases
Microscopic examination
Demyelinating Diseases
Membranes
Axons
Microscopy
Peptides
Central Nervous System
Antibodies

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Genain, C. P., Cannella, B., Hauser, S. L., & Raine, C. S. (1999). Identification of autoantibodies associated with myelin damage in multiple sclerosis. Nature Medicine, 5(2), 170-175. https://doi.org/10.1038/5532

Identification of autoantibodies associated with myelin damage in multiple sclerosis. / Genain, Claude P.; Cannella, Barbara; Hauser, Stephen L.; Raine, Cedric S.

In: Nature Medicine, Vol. 5, No. 2, 02.1999, p. 170-175.

Research output: Contribution to journalArticle

Genain, CP, Cannella, B, Hauser, SL & Raine, CS 1999, 'Identification of autoantibodies associated with myelin damage in multiple sclerosis', Nature Medicine, vol. 5, no. 2, pp. 170-175. https://doi.org/10.1038/5532
Genain, Claude P. ; Cannella, Barbara ; Hauser, Stephen L. ; Raine, Cedric S. / Identification of autoantibodies associated with myelin damage in multiple sclerosis. In: Nature Medicine. 1999 ; Vol. 5, No. 2. pp. 170-175.
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