Identification of a radio-resistant and cycling dermal dendritic cell population in mice and men

Milena Bogunovic, Florent Ginhoux, Amy Wagers, Martine Loubeau, Luis M. Isola, Lauren Lubrano, Vesna Najfeld, Robert G. Phelps, Celia Grosskreutz, Eilleen Scigliano, Paul S. Frenette, Miriam Merad

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

In this study, we explored dermal dendritic cell (DC) homeostasis in mice and humans both in the steady state and after hematopoietic cell transplantation. We discovered that dermal DCs proliferate in situ in mice and human quiescent dermis. In parabiotic mice with separate organs but shared blood circulation, the majority of dermal DCs failed to be replaced by circulating precursors for >6 mo. In lethally irradiated mice injected with donor congenic bone marrow (BM) cells, a subset of recipient DCs remained in the dermis and proliferated locally throughout life. Consistent with these findings, a large proportion of recipient dermal DCs remained in patients' skin after allogeneic hematopoietic cell transplantation, despite complete donor BM chimerism. Collectively, our results oppose the traditional view that DCs are nondividing terminally differentiated cells maintained by circulating precursors and support the new paradigm that tissue DCs have local proliferative properties that control their homeostasis in the steady state. Given the role of residual host tissue DCs in transplant immune reactions, these results suggest that dermal DC homeostasis may contribute to the development of cutaneous graft-versus-host disease in clinical transplantation. JEM

Original languageEnglish (US)
Pages (from-to)2627-2638
Number of pages12
JournalJournal of Experimental Medicine
Volume203
Issue number12
DOIs
StatePublished - Nov 2006
Externally publishedYes

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Langerhans Cells
Radio
Skin
Homeostasis
Population
Cell Transplantation
Dermis
Tissue Donors
Chimerism
Blood Circulation
Graft vs Host Disease
Bone Marrow Cells
Transplantation
Bone Marrow
Transplants

ASJC Scopus subject areas

  • Immunology

Cite this

Bogunovic, M., Ginhoux, F., Wagers, A., Loubeau, M., Isola, L. M., Lubrano, L., ... Merad, M. (2006). Identification of a radio-resistant and cycling dermal dendritic cell population in mice and men. Journal of Experimental Medicine, 203(12), 2627-2638. https://doi.org/10.1084/jem.20060667

Identification of a radio-resistant and cycling dermal dendritic cell population in mice and men. / Bogunovic, Milena; Ginhoux, Florent; Wagers, Amy; Loubeau, Martine; Isola, Luis M.; Lubrano, Lauren; Najfeld, Vesna; Phelps, Robert G.; Grosskreutz, Celia; Scigliano, Eilleen; Frenette, Paul S.; Merad, Miriam.

In: Journal of Experimental Medicine, Vol. 203, No. 12, 11.2006, p. 2627-2638.

Research output: Contribution to journalArticle

Bogunovic, M, Ginhoux, F, Wagers, A, Loubeau, M, Isola, LM, Lubrano, L, Najfeld, V, Phelps, RG, Grosskreutz, C, Scigliano, E, Frenette, PS & Merad, M 2006, 'Identification of a radio-resistant and cycling dermal dendritic cell population in mice and men', Journal of Experimental Medicine, vol. 203, no. 12, pp. 2627-2638. https://doi.org/10.1084/jem.20060667
Bogunovic, Milena ; Ginhoux, Florent ; Wagers, Amy ; Loubeau, Martine ; Isola, Luis M. ; Lubrano, Lauren ; Najfeld, Vesna ; Phelps, Robert G. ; Grosskreutz, Celia ; Scigliano, Eilleen ; Frenette, Paul S. ; Merad, Miriam. / Identification of a radio-resistant and cycling dermal dendritic cell population in mice and men. In: Journal of Experimental Medicine. 2006 ; Vol. 203, No. 12. pp. 2627-2638.
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