Identification of a novel human papillomavirus (HPV97) related to HPV18 and HPV45

Zigui Chen; Leiping Fu; Rolando Herrero; Mark Schiffman; Robert D. Burk

doi:10.1002/ijc.22632

Identification of a novel human papillomavirus (HPV97) related to HPV18 and HPV45

Zigui Chen, Leiping Fu, Rolando Herrero, Mark Schiffman, Robert D. Burk

Pediatrics

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Human papillomavirus (HPV) type 97 was identified and the genome was cloned from cervicovaginal cells of a Costa Rican woman with a normal Pap smear. The HPV97 L1 open reading frame (ORF) was most closely related to HPV45 (84% identity) and HPV18 (79% identity), placing it into the high-risk α7 species. Ectopic expression of the HPV97 E6 and E7 proteins significantly decreased steady state p53 and pRb levels using an in vitro cotransfection assay, respectively. These data suggest that HPV97 shares a most recent common ancestor with HPV18 and HPV45 and should be evaluated in cancer specimens from different geographic populations.

Original language	English (US)
Pages (from-to)	193-198
Number of pages	6
Journal	International Journal of Cancer
Volume	121
Issue number	1
DOIs	https://doi.org/10.1002/ijc.22632
State	Published - Jul 1 2007

Keywords

Evolution
Human papillomavirus
Novel type
Phylogeny

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/ijc.22632

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AU - Chen, Zigui

AU - Fu, Leiping

AU - Herrero, Rolando

AU - Schiffman, Mark

AU - Burk, Robert D.

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AB - Human papillomavirus (HPV) type 97 was identified and the genome was cloned from cervicovaginal cells of a Costa Rican woman with a normal Pap smear. The HPV97 L1 open reading frame (ORF) was most closely related to HPV45 (84% identity) and HPV18 (79% identity), placing it into the high-risk α7 species. Ectopic expression of the HPV97 E6 and E7 proteins significantly decreased steady state p53 and pRb levels using an in vitro cotransfection assay, respectively. These data suggest that HPV97 shares a most recent common ancestor with HPV18 and HPV45 and should be evaluated in cancer specimens from different geographic populations.

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KW - Phylogeny

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Identification of a novel human papillomavirus (HPV97) related to HPV18 and HPV45

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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