Identification of a novel human papillomavirus (HPV97) related to HPV18 and HPV45

Zigui Chen, Leiping Fu, Rolando Herrero, Mark Schiffman, Robert D. Burk

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Human papillomavirus (HPV) type 97 was identified and the genome was cloned from cervicovaginal cells of a Costa Rican woman with a normal Pap smear. The HPV97 L1 open reading frame (ORF) was most closely related to HPV45 (84% identity) and HPV18 (79% identity), placing it into the high-risk α7 species. Ectopic expression of the HPV97 E6 and E7 proteins significantly decreased steady state p53 and pRb levels using an in vitro cotransfection assay, respectively. These data suggest that HPV97 shares a most recent common ancestor with HPV18 and HPV45 and should be evaluated in cancer specimens from different geographic populations.

Original languageEnglish (US)
Pages (from-to)193-198
Number of pages6
JournalInternational Journal of Cancer
Volume121
Issue number1
DOIs
StatePublished - Jul 1 2007

Fingerprint

Papanicolaou Test
Open Reading Frames
Genome
Population
Neoplasms
Proteins
In Vitro Techniques
Ectopic Gene Expression

Keywords

  • Evolution
  • Human papillomavirus
  • Novel type
  • Phylogeny

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Identification of a novel human papillomavirus (HPV97) related to HPV18 and HPV45. / Chen, Zigui; Fu, Leiping; Herrero, Rolando; Schiffman, Mark; Burk, Robert D.

In: International Journal of Cancer, Vol. 121, No. 1, 01.07.2007, p. 193-198.

Research output: Contribution to journalArticle

Chen, Zigui ; Fu, Leiping ; Herrero, Rolando ; Schiffman, Mark ; Burk, Robert D. / Identification of a novel human papillomavirus (HPV97) related to HPV18 and HPV45. In: International Journal of Cancer. 2007 ; Vol. 121, No. 1. pp. 193-198.
@article{7e9660a9e68247fda7c87c6f6fb705c2,
title = "Identification of a novel human papillomavirus (HPV97) related to HPV18 and HPV45",
abstract = "Human papillomavirus (HPV) type 97 was identified and the genome was cloned from cervicovaginal cells of a Costa Rican woman with a normal Pap smear. The HPV97 L1 open reading frame (ORF) was most closely related to HPV45 (84{\%} identity) and HPV18 (79{\%} identity), placing it into the high-risk α7 species. Ectopic expression of the HPV97 E6 and E7 proteins significantly decreased steady state p53 and pRb levels using an in vitro cotransfection assay, respectively. These data suggest that HPV97 shares a most recent common ancestor with HPV18 and HPV45 and should be evaluated in cancer specimens from different geographic populations.",
keywords = "Evolution, Human papillomavirus, Novel type, Phylogeny",
author = "Zigui Chen and Leiping Fu and Rolando Herrero and Mark Schiffman and Burk, {Robert D.}",
year = "2007",
month = "7",
day = "1",
doi = "10.1002/ijc.22632",
language = "English (US)",
volume = "121",
pages = "193--198",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",
number = "1",

}

TY - JOUR

T1 - Identification of a novel human papillomavirus (HPV97) related to HPV18 and HPV45

AU - Chen, Zigui

AU - Fu, Leiping

AU - Herrero, Rolando

AU - Schiffman, Mark

AU - Burk, Robert D.

PY - 2007/7/1

Y1 - 2007/7/1

N2 - Human papillomavirus (HPV) type 97 was identified and the genome was cloned from cervicovaginal cells of a Costa Rican woman with a normal Pap smear. The HPV97 L1 open reading frame (ORF) was most closely related to HPV45 (84% identity) and HPV18 (79% identity), placing it into the high-risk α7 species. Ectopic expression of the HPV97 E6 and E7 proteins significantly decreased steady state p53 and pRb levels using an in vitro cotransfection assay, respectively. These data suggest that HPV97 shares a most recent common ancestor with HPV18 and HPV45 and should be evaluated in cancer specimens from different geographic populations.

AB - Human papillomavirus (HPV) type 97 was identified and the genome was cloned from cervicovaginal cells of a Costa Rican woman with a normal Pap smear. The HPV97 L1 open reading frame (ORF) was most closely related to HPV45 (84% identity) and HPV18 (79% identity), placing it into the high-risk α7 species. Ectopic expression of the HPV97 E6 and E7 proteins significantly decreased steady state p53 and pRb levels using an in vitro cotransfection assay, respectively. These data suggest that HPV97 shares a most recent common ancestor with HPV18 and HPV45 and should be evaluated in cancer specimens from different geographic populations.

KW - Evolution

KW - Human papillomavirus

KW - Novel type

KW - Phylogeny

UR - http://www.scopus.com/inward/record.url?scp=34248550705&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34248550705&partnerID=8YFLogxK

U2 - 10.1002/ijc.22632

DO - 10.1002/ijc.22632

M3 - Article

C2 - 17351898

AN - SCOPUS:34248550705

VL - 121

SP - 193

EP - 198

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 1

ER -