Identification of a novel human papillomavirus (HPV97) related to HPV18 and HPV45

Zigui Chen, Leiping Fu, Rolando Herrero, Mark Schiffman, Robert D. Burk

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Human papillomavirus (HPV) type 97 was identified and the genome was cloned from cervicovaginal cells of a Costa Rican woman with a normal Pap smear. The HPV97 L1 open reading frame (ORF) was most closely related to HPV45 (84% identity) and HPV18 (79% identity), placing it into the high-risk α7 species. Ectopic expression of the HPV97 E6 and E7 proteins significantly decreased steady state p53 and pRb levels using an in vitro cotransfection assay, respectively. These data suggest that HPV97 shares a most recent common ancestor with HPV18 and HPV45 and should be evaluated in cancer specimens from different geographic populations.

Original languageEnglish (US)
Pages (from-to)193-198
Number of pages6
JournalInternational Journal of Cancer
Volume121
Issue number1
DOIs
StatePublished - Jul 1 2007

Keywords

  • Evolution
  • Human papillomavirus
  • Novel type
  • Phylogeny

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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