Identification of a novel human angiopoietin-like gene expressed mainly in heart

Li Zeng; Jianliang Dai; Kang Ying; Enpeng Zhao; Wei Jin; Yin Ye; Jianfeng Dai; Jian Xu; Yi Xie; Yumin Mao

doi:10.1007/s100380300025

Identification of a novel human angiopoietin-like gene expressed mainly in heart

Li Zeng, Jianliang Dai, Kang Ying, Enpeng Zhao, Wei Jin, Yin Ye, Jianfeng Dai, Jian Xu, Yi Xie, Yumin Mao

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

The angiopoietins are an important family of growth factors specific for vascular endothelium, Most of them bind to the TIE2 receptor and are related to regulation of angiogenesis. During large-scale DNA sequencing of the human fetal brain cDNA library, we cloned a novel human angiopoietin-like cDNA and termed it human angiopoietin-like 5 (ANGPTL5). Like other members of the angiopoietin family, ANGPTL5-deduced protein also has an N-terminal cleavable signal peptide, a predicted coiled-coil domain, and a fibrinogen-like domain. The search against the human genome database indicated that ANGPTL5 maps to 11q22. Expression analysis of ANGPTL5 shows that it is mainly expressed in adult human heart.

Original language	English (US)
Pages (from-to)	159-162
Number of pages	4
Journal	Journal of Human Genetics
Volume	48
Issue number	3
DOIs	https://doi.org/10.1007/s100380300025
State	Published - 2003
Externally published	Yes

Keywords

ANGPTL5
Angiopoietin
Coiled-coil domain
Fibrinogenlike domain
Heart

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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10.1007/s100380300025

Cite this

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title = "Identification of a novel human angiopoietin-like gene expressed mainly in heart",

abstract = "The angiopoietins are an important family of growth factors specific for vascular endothelium, Most of them bind to the TIE2 receptor and are related to regulation of angiogenesis. During large-scale DNA sequencing of the human fetal brain cDNA library, we cloned a novel human angiopoietin-like cDNA and termed it human angiopoietin-like 5 (ANGPTL5). Like other members of the angiopoietin family, ANGPTL5-deduced protein also has an N-terminal cleavable signal peptide, a predicted coiled-coil domain, and a fibrinogen-like domain. The search against the human genome database indicated that ANGPTL5 maps to 11q22. Expression analysis of ANGPTL5 shows that it is mainly expressed in adult human heart.",

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author = "Li Zeng and Jianliang Dai and Kang Ying and Enpeng Zhao and Wei Jin and Yin Ye and Jianfeng Dai and Jian Xu and Yi Xie and Yumin Mao",

year = "2003",

doi = "10.1007/s100380300025",

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T1 - Identification of a novel human angiopoietin-like gene expressed mainly in heart

AU - Zeng, Li

AU - Dai, Jianliang

AU - Ying, Kang

AU - Zhao, Enpeng

AU - Jin, Wei

AU - Ye, Yin

AU - Dai, Jianfeng

AU - Xu, Jian

AU - Xie, Yi

AU - Mao, Yumin

PY - 2003

Y1 - 2003

N2 - The angiopoietins are an important family of growth factors specific for vascular endothelium, Most of them bind to the TIE2 receptor and are related to regulation of angiogenesis. During large-scale DNA sequencing of the human fetal brain cDNA library, we cloned a novel human angiopoietin-like cDNA and termed it human angiopoietin-like 5 (ANGPTL5). Like other members of the angiopoietin family, ANGPTL5-deduced protein also has an N-terminal cleavable signal peptide, a predicted coiled-coil domain, and a fibrinogen-like domain. The search against the human genome database indicated that ANGPTL5 maps to 11q22. Expression analysis of ANGPTL5 shows that it is mainly expressed in adult human heart.

AB - The angiopoietins are an important family of growth factors specific for vascular endothelium, Most of them bind to the TIE2 receptor and are related to regulation of angiogenesis. During large-scale DNA sequencing of the human fetal brain cDNA library, we cloned a novel human angiopoietin-like cDNA and termed it human angiopoietin-like 5 (ANGPTL5). Like other members of the angiopoietin family, ANGPTL5-deduced protein also has an N-terminal cleavable signal peptide, a predicted coiled-coil domain, and a fibrinogen-like domain. The search against the human genome database indicated that ANGPTL5 maps to 11q22. Expression analysis of ANGPTL5 shows that it is mainly expressed in adult human heart.

KW - ANGPTL5

KW - Angiopoietin

KW - Coiled-coil domain

KW - Fibrinogenlike domain

KW - Heart

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Identification of a novel human angiopoietin-like gene expressed mainly in heart

Abstract

Keywords

ASJC Scopus subject areas

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