Identification of a novel human angiopoietin-like gene expressed mainly in heart

Li Zeng, Jianliang Dai, Kang Ying, Enpeng Zhao, Wei Jin, Yin Ye, Jianfeng Dai, Jian Xu, Yi Xie, Yumin Mao

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

The angiopoietins are an important family of growth factors specific for vascular endothelium, Most of them bind to the TIE2 receptor and are related to regulation of angiogenesis. During large-scale DNA sequencing of the human fetal brain cDNA library, we cloned a novel human angiopoietin-like cDNA and termed it human angiopoietin-like 5 (ANGPTL5). Like other members of the angiopoietin family, ANGPTL5-deduced protein also has an N-terminal cleavable signal peptide, a predicted coiled-coil domain, and a fibrinogen-like domain. The search against the human genome database indicated that ANGPTL5 maps to 11q22. Expression analysis of ANGPTL5 shows that it is mainly expressed in adult human heart.

Original languageEnglish (US)
Pages (from-to)159-162
Number of pages4
JournalJournal of Human Genetics
Volume48
Issue number3
DOIs
StatePublished - 2003

Keywords

  • ANGPTL5
  • Angiopoietin
  • Coiled-coil domain
  • Fibrinogenlike domain
  • Heart

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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