Identification and characterization of a prostaglandin transporter

Naoaki Kanai, Run Lu, Joseph A. Satriano, Yi Bao, Allan W. Wolkoff, Victor L. Schuster

Research output: Contribution to journalArticle

310 Citations (Scopus)

Abstract

Carrier-mediated prostaglandin transport has been postulated to occur in many tissues. On the basis of sequence homology, the protein of unknown function encoded by the rat matrin F/G complementary DNA was predicted to be an organic anion transporter. Expression of the matrin F/G complementary DNA in HeLa cells or Xenopus oocytes conferred the property of specific transport of prostaglandins. The tissue distribution of matrin F/G messenger RNA and the sensitivity of matrin F/G-induced prostaglandin transport to inhibitors were similar to those of endogenous prostaglandin transport. The protein encoded by the matrin F/G complementary DNA is thus preferably called PGT because it is likely to function as a prostaglandin transporter.

Original languageEnglish (US)
Pages (from-to)866-869
Number of pages4
JournalScience
Volume268
Issue number5212
StatePublished - 1995

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Prostaglandins
Complementary DNA
Prostaglandins G
Organic Anion Transporters
Amino Acid Sequence Homology
Tissue Distribution
Xenopus
HeLa Cells
Oocytes
Messenger RNA
Proteins

ASJC Scopus subject areas

  • General

Cite this

Identification and characterization of a prostaglandin transporter. / Kanai, Naoaki; Lu, Run; Satriano, Joseph A.; Bao, Yi; Wolkoff, Allan W.; Schuster, Victor L.

In: Science, Vol. 268, No. 5212, 1995, p. 866-869.

Research output: Contribution to journalArticle

Kanai, N, Lu, R, Satriano, JA, Bao, Y, Wolkoff, AW & Schuster, VL 1995, 'Identification and characterization of a prostaglandin transporter', Science, vol. 268, no. 5212, pp. 866-869.
Kanai, Naoaki ; Lu, Run ; Satriano, Joseph A. ; Bao, Yi ; Wolkoff, Allan W. ; Schuster, Victor L. / Identification and characterization of a prostaglandin transporter. In: Science. 1995 ; Vol. 268, No. 5212. pp. 866-869.
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