Identification and characterization of a prostaglandin transporter

Naoaki Kanai, Run Lu, Joseph A. Satriano, Yi Bao, Allan W. Wolkoff, Victor L. Schuster

Research output: Contribution to journalArticle

320 Scopus citations

Abstract

Carrier-mediated prostaglandin transport has been postulated to occur in many tissues. On the basis of sequence homology, the protein of unknown function encoded by the rat matrin F/G complementary DNA was predicted to be an organic anion transporter. Expression of the matrin F/G complementary DNA in HeLa cells or Xenopus oocytes conferred the property of specific transport of prostaglandins. The tissue distribution of matrin F/G messenger RNA and the sensitivity of matrin F/G-induced prostaglandin transport to inhibitors were similar to those of endogenous prostaglandin transport. The protein encoded by the matrin F/G complementary DNA is thus preferably called PGT because it is likely to function as a prostaglandin transporter.

Original languageEnglish (US)
Pages (from-to)866-869
Number of pages4
JournalScience
Volume268
Issue number5212
DOIs
StatePublished - 1995

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Identification and characterization of a prostaglandin transporter'. Together they form a unique fingerprint.

Cite this