TY - JOUR
T1 - Identical RNA-protein interactions in vivo and in vitro and a scheme of folding the newly synthesized proteins by ribosomes
AU - Das, Debasis
AU - Samanta, Dibyendu
AU - Hasan, Salman
AU - Das, Anindita
AU - Bhattacharya, Arpita
AU - Dasgupta, Santanu
AU - Chakrabarti, Abhijit
AU - Ghorai, Pradip
AU - Das Gupta, Chanchal
PY - 2012/10/26
Y1 - 2012/10/26
N2 - Background: Ribosomal PTC acts as a protein folding modulator in vivo and in vitro. Results: A fixed set of nucleotides in the PTC interacts to fold polypeptides in vivo and in vitro. Conclusion: Folding all proteins through interaction with the same set of nucleotides in PTC implies they have intrinsic homology. Significance: Hundreds of proteins showed an identical cumulative hydrophobicity plot for amino acids.
AB - Background: Ribosomal PTC acts as a protein folding modulator in vivo and in vitro. Results: A fixed set of nucleotides in the PTC interacts to fold polypeptides in vivo and in vitro. Conclusion: Folding all proteins through interaction with the same set of nucleotides in PTC implies they have intrinsic homology. Significance: Hundreds of proteins showed an identical cumulative hydrophobicity plot for amino acids.
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U2 - 10.1074/jbc.M112.396127
DO - 10.1074/jbc.M112.396127
M3 - Article
C2 - 22932895
AN - SCOPUS:84868231123
SN - 0021-9258
VL - 287
SP - 37508
EP - 37521
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 44
ER -