Identical RNA-protein interactions in vivo and in vitro and a scheme of folding the newly synthesized proteins by ribosomes

Debasis Das, Dibyendu Samanta, Salman Hasan, Anindita Das, Arpita Bhattacharya, Santanu Dasgupta, Abhijit Chakrabarti, Pradip Ghorai, Chanchal Das Gupta

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Background: Ribosomal PTC acts as a protein folding modulator in vivo and in vitro. Results: A fixed set of nucleotides in the PTC interacts to fold polypeptides in vivo and in vitro. Conclusion: Folding all proteins through interaction with the same set of nucleotides in PTC implies they have intrinsic homology. Significance: Hundreds of proteins showed an identical cumulative hydrophobicity plot for amino acids.

Original languageEnglish (US)
Pages (from-to)37508-37521
Number of pages14
JournalJournal of Biological Chemistry
Volume287
Issue number44
DOIs
StatePublished - Oct 26 2012

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Das, D., Samanta, D., Hasan, S., Das, A., Bhattacharya, A., Dasgupta, S., Chakrabarti, A., Ghorai, P., & Das Gupta, C. (2012). Identical RNA-protein interactions in vivo and in vitro and a scheme of folding the newly synthesized proteins by ribosomes. Journal of Biological Chemistry, 287(44), 37508-37521. https://doi.org/10.1074/jbc.M112.396127