Identical RNA-protein interactions in vivo and in vitro and a scheme of folding the newly synthesized proteins by ribosomes

Debasis Das, Dibyendu Samanta, Salman Hasan, Anindita Das, Arpita Bhattacharya, Santanu Dasgupta, Abhijit Chakrabarti, Pradip Ghorai, Chanchal Das Gupta

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Ribosomal PTC acts as a protein folding modulator in vivo and in vitro. Results: A fixed set of nucleotides in the PTC interacts to fold polypeptides in vivo and in vitro. Conclusion: Folding all proteins through interaction with the same set of nucleotides in PTC implies they have intrinsic homology. Significance: Hundreds of proteins showed an identical cumulative hydrophobicity plot for amino acids.

Original languageEnglish (US)
Pages (from-to)37508-37521
Number of pages14
JournalJournal of Biological Chemistry
Volume287
Issue number44
DOIs
StatePublished - Oct 26 2012
Externally publishedYes

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Factor IX
Ribosomes
Protein Folding
RNA
Nucleotides
Protein folding
Proteins
Hydrophobicity
Hydrophobic and Hydrophilic Interactions
Modulators
Amino Acids
Peptides
In Vitro Techniques

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Identical RNA-protein interactions in vivo and in vitro and a scheme of folding the newly synthesized proteins by ribosomes. / Das, Debasis; Samanta, Dibyendu; Hasan, Salman; Das, Anindita; Bhattacharya, Arpita; Dasgupta, Santanu; Chakrabarti, Abhijit; Ghorai, Pradip; Das Gupta, Chanchal.

In: Journal of Biological Chemistry, Vol. 287, No. 44, 26.10.2012, p. 37508-37521.

Research output: Contribution to journalArticle

Das, D, Samanta, D, Hasan, S, Das, A, Bhattacharya, A, Dasgupta, S, Chakrabarti, A, Ghorai, P & Das Gupta, C 2012, 'Identical RNA-protein interactions in vivo and in vitro and a scheme of folding the newly synthesized proteins by ribosomes', Journal of Biological Chemistry, vol. 287, no. 44, pp. 37508-37521. https://doi.org/10.1074/jbc.M112.396127
Das, Debasis ; Samanta, Dibyendu ; Hasan, Salman ; Das, Anindita ; Bhattacharya, Arpita ; Dasgupta, Santanu ; Chakrabarti, Abhijit ; Ghorai, Pradip ; Das Gupta, Chanchal. / Identical RNA-protein interactions in vivo and in vitro and a scheme of folding the newly synthesized proteins by ribosomes. In: Journal of Biological Chemistry. 2012 ; Vol. 287, No. 44. pp. 37508-37521.
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