ICG-loaded microbubbles for multimodal billiary imaging in cholecystectomy

Ruogu Qin, W. Scott Melvin, Ronald X. Xu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A dual-mode imaging technique has been developed for intraoperative imaging of bile ducts and real-time identification of iatrogenic injuries in cholecystectomy. The technique is based on ultrasound (US) and fluorescence (FL) imaging of a dual-mode microbubble (MB) agent comprising a poly (lactic-co-glycolic acid) (PLGA) shell and a core of Indocyanine Green. During cholecystectomy, a clinical US probe is used to localize the bile duct structure after bolus injection of dual-mode MBs. As the surrounding adipose tissue is removed and the Calot's triangle is exposed, FL imaging is used to identify the MB distribution and to determine the potential bile duct injury. The contrast-enhanced bile duct imaging technique has been demonstrated in both a surgical simulation model and an ex vivo porcine tissue model under two surgical scenarios. The first scenario simulates the correct procedure where the cystic duct is clipped. The second scenario simulates the incorrect procedure where the common bile duct is clipped, leading to consequent bile duct injury. Benchtop experiments in both the phantom and the ex vivo models show that the dual-mode imaging technique is able to identify the potential bile duct injury during cholecystectomy. A phantom system has also been established for future device calibration and surgical training in image-guided cholecystectomy. Further in vivo animal validation tests are necessary before the technique can be implemented in a clinical setting.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8553
DOIs
StatePublished - 2012
Externally publishedYes
EventOptics in Health Care and Biomedical Optics V - Beijing, China
Duration: Nov 5 2012Nov 7 2012

Other

OtherOptics in Health Care and Biomedical Optics V
CountryChina
CityBeijing
Period11/5/1211/7/12

Fingerprint

Multimodal Imaging
Microbubbles
Cholecystectomy
Bile Ducts
ducts
Ducts
Imaging techniques
Optical Imaging
Wounds and Injuries
imaging techniques
Anatomic Models
Cystic Duct
Indocyanine Green
Ultrasonics
Fluorescence
Common Bile Duct
adipose tissues
Tissue
fluorescence
Calibration

Keywords

  • bile duct injury
  • cholecystectomy
  • fluorescence imaging
  • Indocyanine green
  • microbubble
  • ultrasound imaging

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Qin, R., Melvin, W. S., & Xu, R. X. (2012). ICG-loaded microbubbles for multimodal billiary imaging in cholecystectomy. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8553). [85531F] https://doi.org/10.1117/12.1000020

ICG-loaded microbubbles for multimodal billiary imaging in cholecystectomy. / Qin, Ruogu; Melvin, W. Scott; Xu, Ronald X.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8553 2012. 85531F.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Qin, R, Melvin, WS & Xu, RX 2012, ICG-loaded microbubbles for multimodal billiary imaging in cholecystectomy. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 8553, 85531F, Optics in Health Care and Biomedical Optics V, Beijing, China, 11/5/12. https://doi.org/10.1117/12.1000020
Qin R, Melvin WS, Xu RX. ICG-loaded microbubbles for multimodal billiary imaging in cholecystectomy. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8553. 2012. 85531F https://doi.org/10.1117/12.1000020
Qin, Ruogu ; Melvin, W. Scott ; Xu, Ronald X. / ICG-loaded microbubbles for multimodal billiary imaging in cholecystectomy. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8553 2012.
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