TY - JOUR
T1 - Hypoxia causes mitochondrial dysfunction and brain memory disorder in a manner mediated by the reduction of Cirbp
AU - Liu, Ying
AU - Xue, Chong
AU - Lu, Huanyu
AU - Zhou, Yang
AU - Guan, Ruili
AU - Wang, Jiye
AU - Zhang, Qian
AU - Ke, Tao
AU - Aschner, Michael
AU - Zhang, Wenbin
AU - Luo, Wenjing
N1 - Publisher Copyright:
© 2021
PY - 2022/2/1
Y1 - 2022/2/1
N2 - Environmental hypoxic hazard has increasingly become a global public health issue, with impelling evidences supporting the relation between hypoxia and cognitive disorders. As a potent stressor, hypoxia causes mitochondrial dysfunction with insufficient energy production, thus the formation of brain memory disorder. Yet, the underlying molecular mechanism/s against hypoxia induced injury have yet to be identified. Here, we report that cold inducible RNA binding protein (Cirbp) attenuates hypoxia induced insufficient energy production and oxidative stress. Further analyses show that Cirbp sustains protein levels of respiratory chain complexes II (SDHB) and IV (MT-CO1), and directly binds the 3’UTR of Atp5g3 to control mitochondrial homeostasis and ATP biogenesis upon hypoxic stress. Altogether, our data establish Cirbp as a critical protective factor against hypoxic health hazard and provide novel insights into its latent regulation network.
AB - Environmental hypoxic hazard has increasingly become a global public health issue, with impelling evidences supporting the relation between hypoxia and cognitive disorders. As a potent stressor, hypoxia causes mitochondrial dysfunction with insufficient energy production, thus the formation of brain memory disorder. Yet, the underlying molecular mechanism/s against hypoxia induced injury have yet to be identified. Here, we report that cold inducible RNA binding protein (Cirbp) attenuates hypoxia induced insufficient energy production and oxidative stress. Further analyses show that Cirbp sustains protein levels of respiratory chain complexes II (SDHB) and IV (MT-CO1), and directly binds the 3’UTR of Atp5g3 to control mitochondrial homeostasis and ATP biogenesis upon hypoxic stress. Altogether, our data establish Cirbp as a critical protective factor against hypoxic health hazard and provide novel insights into its latent regulation network.
KW - Cognition and memory
KW - Cold inducible RNA-binding protein
KW - Dysfunction
KW - Hypoxia
KW - Mitochondrion
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U2 - 10.1016/j.scitotenv.2021.151228
DO - 10.1016/j.scitotenv.2021.151228
M3 - Article
C2 - 34715218
AN - SCOPUS:85118585021
SN - 0048-9697
VL - 806
JO - Science of the Total Environment
JF - Science of the Total Environment
M1 - 151228
ER -