Hypothalamic-pituitary-adrenal axis dysregulation in depersonalization disorder

Daphne Simeon, Orna Guralnik, Margaret Knutelska, Eric Hollander, James Schmeidler

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Background: The purpose of this preliminary study was to investigate HPA axis function in dissociation. Methods: Nine subjects with DSM-IV depersonalization disorder (DPD), without lifetime Posttraumatic Stress Disorder (PTSD) or current major depression, were compared to nine healthy comparison (HC) subjects of comparable age and gender. Results: DPD subjects demonstrated significant hyposuppression to low-dose dexamethasone administration and significantly elevated morning plasma cortisol levels when covaried for depression scores, but no difference in 24-hour urinary cortisol excretion. Dissociation scores powerfully predicted suppression whereas depression scores did not contribute to the prediction. Conclusions: Primary dissociative conditions, such as depersonalization disorder, may be associated with a pattern of HPA axis dysregulation that differs from PTSD and merits further study.

Original languageEnglish (US)
Pages (from-to)793-795
Number of pages3
JournalNeuropsychopharmacology
Volume25
Issue number5
DOIs
Publication statusPublished - Jan 1 2001
Externally publishedYes

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Keywords

  • Cortisol
  • Depersonalization
  • Dexamethasone
  • Dissociation
  • HPA axis
  • Suppression

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

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