Hypothalamic KATP channels control hepatic glucose production

Alessandro Pocal, Tony K T Lam, Roger Gutierrez-Juarez, Silvana Obici, Gary J. Schwartz, Joseph Bryan, Lydia Aguilar-Bryan, Luciano Rossetti

Research output: Contribution to journalArticle

442 Citations (Scopus)

Abstract

Obesity is the driving force behind the worldwide increase in the prevalence of type 2 diabetes mellitus1,2. Hyperglycaemia is a hallmark of diabetes and is largely due to increased hepatic gluconeogenesis3. The medial hypothalamus is a major integrator of nutritional and hormonal signals1,2,4, which play pivotal roles not only in the regulation of energy balance but also in the modulation of liver glucose output5,6. Bidirectional changes in hypothalamic insulin signalling therefore result in parallel changes in both energy balance 7-10 and glucose metabolism5. Here we show that activation of ATP-sensitive potassium (KATP) channels11 in the mediobasal hypothalamus is sufficient to lower blood glucose levels through inhibition of hepatic gluconeogenesis. Finally, the infusion of a K ATP blocker within the mediobasal hypothalamus, or the surgical resection of the hepatic branch of the vagus nerve, negates the effects of central insulin and halves the effects of systemic insulin on hepatic glucose production. Consistent with these results, mice lacking the SUR1 subunit of the KATP channel12 are resistant to the inhibitory action of insulin on gluconeogenesis. These findings suggest that activation of hypothalamic KATP channels normally restrains hepatic gluconeogenesis, and that any alteration within this central nervous system/liver circuit can contribute to diabetic hyperglycaemia.

Original languageEnglish (US)
Pages (from-to)1026-1031
Number of pages6
JournalNature
Volume434
Issue number7036
DOIs
StatePublished - Apr 21 2005

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KATP Channels
Glucose
Liver
Gluconeogenesis
Insulin
Hyperglycemia
Hypothalamus
Adenosine Triphosphate
Middle Hypothalamus
Vagus Nerve
Type 2 Diabetes Mellitus
Blood Glucose
Potassium
Central Nervous System
Obesity

ASJC Scopus subject areas

  • General

Cite this

Pocal, A., Lam, T. K. T., Gutierrez-Juarez, R., Obici, S., Schwartz, G. J., Bryan, J., ... Rossetti, L. (2005). Hypothalamic KATP channels control hepatic glucose production. Nature, 434(7036), 1026-1031. https://doi.org/10.1038/nature03439

Hypothalamic KATP channels control hepatic glucose production. / Pocal, Alessandro; Lam, Tony K T; Gutierrez-Juarez, Roger; Obici, Silvana; Schwartz, Gary J.; Bryan, Joseph; Aguilar-Bryan, Lydia; Rossetti, Luciano.

In: Nature, Vol. 434, No. 7036, 21.04.2005, p. 1026-1031.

Research output: Contribution to journalArticle

Pocal, A, Lam, TKT, Gutierrez-Juarez, R, Obici, S, Schwartz, GJ, Bryan, J, Aguilar-Bryan, L & Rossetti, L 2005, 'Hypothalamic KATP channels control hepatic glucose production', Nature, vol. 434, no. 7036, pp. 1026-1031. https://doi.org/10.1038/nature03439
Pocal A, Lam TKT, Gutierrez-Juarez R, Obici S, Schwartz GJ, Bryan J et al. Hypothalamic KATP channels control hepatic glucose production. Nature. 2005 Apr 21;434(7036):1026-1031. https://doi.org/10.1038/nature03439
Pocal, Alessandro ; Lam, Tony K T ; Gutierrez-Juarez, Roger ; Obici, Silvana ; Schwartz, Gary J. ; Bryan, Joseph ; Aguilar-Bryan, Lydia ; Rossetti, Luciano. / Hypothalamic KATP channels control hepatic glucose production. In: Nature. 2005 ; Vol. 434, No. 7036. pp. 1026-1031.
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