Hypothalamic inflammation

a double-edged sword to nutritional diseases.

Dongsheng Cai, Tiewen Liu

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

The hypothalamus is one of the master regulators of various physiological processes, including energy balance and nutrient metabolism. These regulatory functions are mediated by discrete hypothalamic regions that integrate metabolic sensing with neuroendocrine and neural controls of systemic physiology. Neurons and nonneuronal cells in these hypothalamic regions act supportively to execute metabolic regulations. Under conditions of brain and hypothalamic inflammation, which may result from overnutrition-induced intracellular stresses or disease-associated systemic inflammatory factors, extracellular and intracellular environments of hypothalamic cells are disrupted, leading to central metabolic dysregulations and various diseases. Recent research has begun to elucidate the effects of hypothalamic inflammation in causing diverse components of metabolic syndrome leading to diabetes and cardiovascular disease. These new understandings have provocatively expanded previous knowledge on the cachectic roles of brain inflammatory response in diseases, such as infections and cancers. This review describes the molecular and cellular characteristics of hypothalamic inflammation in metabolic syndrome and related diseases as opposed to cachectic diseases, and also discusses concepts and potential applications of inhibiting central/hypothalamic inflammation to treat nutritional diseases.

Original languageEnglish (US)
JournalAnnals of the New York Academy of Sciences
Volume1243
DOIs
StatePublished - Dec 2011

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Inflammation
Overnutrition
Brain
Physiological Phenomena
Encephalitis
Physiology
Hypothalamus
Medical problems
Sword
Energy balance
Metabolism
Cardiovascular Diseases
Nutrients
Neurons
Food
Infection
Research
Neoplasms
Syndrome
Cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Hypothalamic inflammation : a double-edged sword to nutritional diseases. / Cai, Dongsheng; Liu, Tiewen.

In: Annals of the New York Academy of Sciences, Vol. 1243, 12.2011.

Research output: Contribution to journalArticle

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