Hypertension impairs vascular reactivity in the pediatric brain

Linda J. Wong, Juan C. Kupferman, Isak Prohovnik, Fenella J. Kirkham, Sharon Goodman, Kara Paterno, Madhu Sharma, Yuri Brosgol, Steven G. Pavlakis

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Background and Purpose- Chronic hypertension impairs cerebrovascular regulation in adults, but its effects on the pediatric population are unknown. The objective of this study was to investigate cerebrovascular abnormalities in hypertensive children and adolescents. Methods- Sixty-four children and adolescents aged 7 to 20 years underwent transcranial Doppler examinations of the middle cerebral artery at the time of rebreathing CO2. Time-averaged maximum mean cerebral blood flow velocity and end-tidal CO2 were used to quantify cerebrovascular reactivity during hypercapnia. Patients were clinically categorized as hypertensive, prehypertensive, or white coat hypertensive based on 24-hour ambulatory blood pressure measurements. Their reactivities were compared with 9 normotensive control subjects and evaluated against baseline mean blood pressure z-scores and loads. Results- Untreated hypertensive children had significantly lower hypercapnic reactivity than normotensive children (2.556±1.832 cm/s • mm Hg versus 4.256±1.334 cm/s • mm Hg, P

Original languageEnglish (US)
Pages (from-to)1834-1838
Number of pages5
JournalStroke
Volume42
Issue number7
DOIs
StatePublished - Jul 2011
Externally publishedYes

Fingerprint

Blood Vessels
Pediatrics
Hypertension
Brain
Cerebrovascular Circulation
Blood Pressure
Blood Flow Velocity
Hypercapnia
Middle Cerebral Artery
Population

Keywords

  • cerebral blood flow
  • cerebrovascular reactivity
  • hypercapnia
  • hypertension
  • pediatric
  • transcranial Doppler

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing

Cite this

Wong, L. J., Kupferman, J. C., Prohovnik, I., Kirkham, F. J., Goodman, S., Paterno, K., ... Pavlakis, S. G. (2011). Hypertension impairs vascular reactivity in the pediatric brain. Stroke, 42(7), 1834-1838. https://doi.org/10.1161/STROKEAHA.110.607606

Hypertension impairs vascular reactivity in the pediatric brain. / Wong, Linda J.; Kupferman, Juan C.; Prohovnik, Isak; Kirkham, Fenella J.; Goodman, Sharon; Paterno, Kara; Sharma, Madhu; Brosgol, Yuri; Pavlakis, Steven G.

In: Stroke, Vol. 42, No. 7, 07.2011, p. 1834-1838.

Research output: Contribution to journalArticle

Wong, LJ, Kupferman, JC, Prohovnik, I, Kirkham, FJ, Goodman, S, Paterno, K, Sharma, M, Brosgol, Y & Pavlakis, SG 2011, 'Hypertension impairs vascular reactivity in the pediatric brain', Stroke, vol. 42, no. 7, pp. 1834-1838. https://doi.org/10.1161/STROKEAHA.110.607606
Wong LJ, Kupferman JC, Prohovnik I, Kirkham FJ, Goodman S, Paterno K et al. Hypertension impairs vascular reactivity in the pediatric brain. Stroke. 2011 Jul;42(7):1834-1838. https://doi.org/10.1161/STROKEAHA.110.607606
Wong, Linda J. ; Kupferman, Juan C. ; Prohovnik, Isak ; Kirkham, Fenella J. ; Goodman, Sharon ; Paterno, Kara ; Sharma, Madhu ; Brosgol, Yuri ; Pavlakis, Steven G. / Hypertension impairs vascular reactivity in the pediatric brain. In: Stroke. 2011 ; Vol. 42, No. 7. pp. 1834-1838.
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