Hyperphosphatasemia: Report of three cases

Akbar Bonakdarpour, Catherine Maldjian, Sharon Weiss, Neil Roach, Eric Stein

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


We report the radiographic findings in three cases of hyperphosphatasemia. Often classified as a congenital bone dysplasia, the skeletal manifestations of this disorder are diagnostic. These features simulate Paget's disease both radiographically and with respect to salient biochemical markers. Typically, presentation is at early childhood with skull deformity, refusal to weight bear, and bowing of the extremities. Notable radiographic features include bowing of the long bones, thickening of the cortex, osteopenia, coarsened trabecular pattern, expansion of the medullary cavity, and thickening of the intramembranous portion of the calvarium. Histologic features include absence of lamellar bone and haversian systems, with thick osteoid seams and increased number of osteoclasts. An autosomal recessive pattern of inheritance has been suggested, although autosomal dominant varieties have been postulated. (C) 2000 Published by Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)54-58
Number of pages5
JournalEuropean Journal of Radiology
Issue number1
StatePublished - 2000
Externally publishedYes


  • Congenital bone dysplasia
  • Hyperphosphatasemia
  • Idiopathic hyperphosphatasia

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Hyperphosphatasemia: Report of three cases'. Together they form a unique fingerprint.

Cite this