TY - JOUR
T1 - Hyperlipoproteinemia in spontaneously diabetic guinea pigs
AU - Arbeeny, Cynthia M.
AU - Nordin, Charles
AU - Edelstein, Diane
AU - Stram, Nadine
AU - Gibbons, Nora
AU - Eder, Howard A.
N1 - Funding Information:
From the Department of Medicine, Albert Einstein College of Medicine, Bronx, NY. Supported by Research Grant Nos. HL 26817 and 32688 from the National Institutes of Health, and a Feasibility Study Award from the Diabetes Research and Training Center at Albert Einstein (5P60-AM-20541). Dr Arbeeny is a recipient of an Established Fellowship Award, and Dr Nordin is a recipient of a Richard Rogers Investigatorship Award from the American Heart Association, New York City Afifiate. Address reprint requests to Cynthia M. Arbeeny, PhD, Squibb Institute for Medical Research, PO Box 4000, Princeton, NJ 08543-4000. 0 I989 by W.B. Saunders Company. 0026-0495/89/3809-0014g3.00/0
PY - 1989/9
Y1 - 1989/9
N2 - A colony of Hartley guinea pigs that exhibit hyperglycemia, glucosuria, and hypertriglyceridemia characteristic of human diabetes mellitus was developed. Initially, a group of guinea pigs that had normal serum glucose concentrations (≤200 mg/dL of serum) at 3 to 4 weeks of age was obtained; however, in some of the animals progressively severe hyperglycemia (300 to 500 mg/dL of serum) and glucosuria (2 g of glucose/24 h) occurred as the animals matured. In addition, the animals exhibiting hyperglycemia and glucosuria had plasma insulin concentrations that were similar to those animals that were not hyperglycemic. The diabetic animals were found to be hypertriglyceridemic, with plasma triglyceride levels of 140 to 290 mg/dL at four months of age. Nondiabetic animals (plasma glucose concentration of ≤200 mg/dL and no glucosuria) had plasma triglyceride concentrations between 37 and 76 mg/dL. Lipoprotein analysis of plasma from nondiabetic and diabetic animals indicated that the diabetics had a fourfold increase in VLDL triglyceride and protein concentrations. The VLDL had an abnormal apolipoprotein composition and had reduced levels of apoprotein-E. The progeny from the mating of diabetic males and females also exhibited the diabetic trait, suggesting that the origin of the disease is genetic. This colony of guinea pigs is being further investigated as a suitable model for the study of the hyperlipoproteinemia of human noninsulin-dependent diabetes mellitus.
AB - A colony of Hartley guinea pigs that exhibit hyperglycemia, glucosuria, and hypertriglyceridemia characteristic of human diabetes mellitus was developed. Initially, a group of guinea pigs that had normal serum glucose concentrations (≤200 mg/dL of serum) at 3 to 4 weeks of age was obtained; however, in some of the animals progressively severe hyperglycemia (300 to 500 mg/dL of serum) and glucosuria (2 g of glucose/24 h) occurred as the animals matured. In addition, the animals exhibiting hyperglycemia and glucosuria had plasma insulin concentrations that were similar to those animals that were not hyperglycemic. The diabetic animals were found to be hypertriglyceridemic, with plasma triglyceride levels of 140 to 290 mg/dL at four months of age. Nondiabetic animals (plasma glucose concentration of ≤200 mg/dL and no glucosuria) had plasma triglyceride concentrations between 37 and 76 mg/dL. Lipoprotein analysis of plasma from nondiabetic and diabetic animals indicated that the diabetics had a fourfold increase in VLDL triglyceride and protein concentrations. The VLDL had an abnormal apolipoprotein composition and had reduced levels of apoprotein-E. The progeny from the mating of diabetic males and females also exhibited the diabetic trait, suggesting that the origin of the disease is genetic. This colony of guinea pigs is being further investigated as a suitable model for the study of the hyperlipoproteinemia of human noninsulin-dependent diabetes mellitus.
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U2 - 10.1016/0026-0495(89)90238-2
DO - 10.1016/0026-0495(89)90238-2
M3 - Article
C2 - 2770534
AN - SCOPUS:0024462842
VL - 38
SP - 895
EP - 900
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
SN - 0026-0495
IS - 9
ER -