Hyperglycemia-induced oxidative brain injury

Therapeutic effects of Cola nitida infusion against redox imbalance, cerebellar neuronal insults, and upregulated Nrf2 expression in type 2 diabetic rats

Ochuko L. Erukainure, Omamuyovwi M. Ijomone, Olajumoke A. Oyebode, Chika I. Chukwuma, Michael Aschner, Md Shahidul Islam

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The therapeutic effect of the hot water infusion of Cola nitida against hyperglycemia-induced neurotoxicity, cerebellar neurodegeneration and elemental deregulations was investigated in fructose-streptozotocin induced rat model of type 2 diabetes (T2D). A diabetic group was administered drinking water, two other diabetic groups were treated with C. nitida at 150 and 300 mg/kg bodyweight respectively, while another group was administered metformin (200 mg/kg bodyweight). Two other groups consisting of normal rats, were administered drinking water and C. nitida (300 mg/kg bodyweight). After 6 weeks of treatment, their brains were collected. Treatment with C. nitida led to suppression of oxidative stress, significantly elevating reduced glutathione (GSH) levels, superoxide dismutase and catalase activities, concomitant with depletion of malondialdehyde (MDA) levels. Acetylcholinesterase and ATPase activities were significantly inhibited in C. nitida-treated diabetic rats. Histological and microscopic analysis also revealed a restorative effect of C. nitida on T2D-altered distribution of elements, neurons and axonal nodes. Treatment with C. nitida also led to significant inhibition of Nrf2 expression in the cerebellar cortex. These results suggest the therapeutic effects of C. nitida in maintenance of the neuronal integrity and antioxidant status of the brain in T2D. These neuroprotective activities can be attributed to the identified alkaloid, caffeine in the infusion.

Original languageEnglish (US)
Pages (from-to)206-217
Number of pages12
JournalFood and Chemical Toxicology
Volume127
DOIs
StatePublished - May 1 2019

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Therapeutic Uses
hyperglycemia
Medical problems
Hyperglycemia
Brain Injuries
Oxidation-Reduction
Rats
Brain
brain
Drinking Water
therapeutics
rats
Oxidative stress
Deregulation
Metformin
noninsulin-dependent diabetes mellitus
Acetylcholinesterase
Type 2 Diabetes Mellitus
Streptozocin
Caffeine

Keywords

  • Cola nitida
  • Neurodegeneration
  • Nrf2
  • SEM-EDX
  • Type 2 diabetes

ASJC Scopus subject areas

  • Food Science
  • Toxicology

Cite this

Hyperglycemia-induced oxidative brain injury : Therapeutic effects of Cola nitida infusion against redox imbalance, cerebellar neuronal insults, and upregulated Nrf2 expression in type 2 diabetic rats. / Erukainure, Ochuko L.; Ijomone, Omamuyovwi M.; Oyebode, Olajumoke A.; Chukwuma, Chika I.; Aschner, Michael; Islam, Md Shahidul.

In: Food and Chemical Toxicology, Vol. 127, 01.05.2019, p. 206-217.

Research output: Contribution to journalArticle

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abstract = "The therapeutic effect of the hot water infusion of Cola nitida against hyperglycemia-induced neurotoxicity, cerebellar neurodegeneration and elemental deregulations was investigated in fructose-streptozotocin induced rat model of type 2 diabetes (T2D). A diabetic group was administered drinking water, two other diabetic groups were treated with C. nitida at 150 and 300 mg/kg bodyweight respectively, while another group was administered metformin (200 mg/kg bodyweight). Two other groups consisting of normal rats, were administered drinking water and C. nitida (300 mg/kg bodyweight). After 6 weeks of treatment, their brains were collected. Treatment with C. nitida led to suppression of oxidative stress, significantly elevating reduced glutathione (GSH) levels, superoxide dismutase and catalase activities, concomitant with depletion of malondialdehyde (MDA) levels. Acetylcholinesterase and ATPase activities were significantly inhibited in C. nitida-treated diabetic rats. Histological and microscopic analysis also revealed a restorative effect of C. nitida on T2D-altered distribution of elements, neurons and axonal nodes. Treatment with C. nitida also led to significant inhibition of Nrf2 expression in the cerebellar cortex. These results suggest the therapeutic effects of C. nitida in maintenance of the neuronal integrity and antioxidant status of the brain in T2D. These neuroprotective activities can be attributed to the identified alkaloid, caffeine in the infusion.",
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