Hypercapnic arousal responses in Prader-Willi syndrome

F. R. Livingston, Raanan Arens, S. L. Bailey, T. G. Keens, S. L D Ward

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Study objective: Prader-Willi syndrome (PWS) is characterized by a number of abnormalities of hypothalamic function, such as hyperphagia, short stature, temperature instability, hypogonadotropic hypogonadism, and neurosecretory growth hormone deficiency. Patients with PWS are reported to have sleep-disordered breathing and have blunted hypercapnic ventilatory responses secondary to abnormal peripheral chemoreceptor function. Thus, we hypothesized that hypercapnic arousal responses would be abnormal in PWS. Design: Hypercapnic arousal responses were tested in ten nonobese children and adults with PWS, aged 17.7±2.5 (SEM) years, 70% female, and nine control subjects, aged 14.2±2.6 years, 67% female. Hypercapnic challenges were performed during stage 3/4 non-rapid eye movement sleep. Results: The PWS subjects had a significantly higher arousal threshold to hypercapnia compared with the controls (53±1.0 vs 46±1.7 mm Hg; p<0.01). The PWS subjects had significantly higher baseline end-tidalCO2 levels (42±0.8 vs 38±1.1 mm Hg; p<0.01) and more central apneas greater than 15 s/h of sleep (1.5±0.3 vs 0.1±0.1; p<0.01). Conclusions: Elevated hypercapnic arousal thresholds during sleep are found in PWS subjects; these may be a manifestation of abnormal peripheral chemoreceptor function and may further contribute to sleep-disordered breathing in PWS patients.

Original languageEnglish (US)
Pages (from-to)1627-1631
Number of pages5
JournalChest
Volume108
Issue number6
StatePublished - 1995
Externally publishedYes

Fingerprint

Prader-Willi Syndrome
Arousal
Sleep
Sleep Apnea Syndromes
Central Sleep Apnea
Hyperphagia
Hypogonadism
Hypercapnia
Eye Movements
Growth Hormone
Temperature

Keywords

  • arousal
  • hypercapia
  • Prader-Willi syndrome
  • respiratory control

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Livingston, F. R., Arens, R., Bailey, S. L., Keens, T. G., & Ward, S. L. D. (1995). Hypercapnic arousal responses in Prader-Willi syndrome. Chest, 108(6), 1627-1631.

Hypercapnic arousal responses in Prader-Willi syndrome. / Livingston, F. R.; Arens, Raanan; Bailey, S. L.; Keens, T. G.; Ward, S. L D.

In: Chest, Vol. 108, No. 6, 1995, p. 1627-1631.

Research output: Contribution to journalArticle

Livingston, FR, Arens, R, Bailey, SL, Keens, TG & Ward, SLD 1995, 'Hypercapnic arousal responses in Prader-Willi syndrome', Chest, vol. 108, no. 6, pp. 1627-1631.
Livingston FR, Arens R, Bailey SL, Keens TG, Ward SLD. Hypercapnic arousal responses in Prader-Willi syndrome. Chest. 1995;108(6):1627-1631.
Livingston, F. R. ; Arens, Raanan ; Bailey, S. L. ; Keens, T. G. ; Ward, S. L D. / Hypercapnic arousal responses in Prader-Willi syndrome. In: Chest. 1995 ; Vol. 108, No. 6. pp. 1627-1631.
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