Hypercalcemia with suppressed parathyroid hormone in Burkitt's lymphoma

Allen M. Spiegel, M. Greene, I. Magrath, J. Balow, S. Marx, G. D. Aurbach

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Two patients with Burkitt's lymphoma presented with severe hypercalcemia, a previously unreported complication of this tumor. Roentgenograms and radionuclide scans showed multiple osteolytic lesions in both patients. Plasma parathyroid hormone (PTH) was undetectable during the hypercalcemic phase. Chemotherapy was followed by rapid tumor lysis, hyperphosphatemia, phosphaturia and hypocalcemia. The hypocalcemic phase persisted for two weeks despite rapid normalization of serum phosphorus and renal function. Measurement of urinary cyclic AMP, an index of PTH action, indicated that parathyroid function had been suppressed by the hypercalcemia and remained suppressed for almost one week despite marked hypocalcemia.

Original languageEnglish (US)
Pages (from-to)691-695
Number of pages5
JournalThe American journal of medicine
Volume64
Issue number4
DOIs
StatePublished - 1978
Externally publishedYes

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Burkitt Lymphoma
Hypocalcemia
Hypercalcemia
Parathyroid Hormone
Familial Hypophosphatemia
Hyperphosphatemia
Radioisotopes
Cyclic AMP
Phosphorus
Neoplasms
Kidney
Drug Therapy
Serum

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Hypercalcemia with suppressed parathyroid hormone in Burkitt's lymphoma. / Spiegel, Allen M.; Greene, M.; Magrath, I.; Balow, J.; Marx, S.; Aurbach, G. D.

In: The American journal of medicine, Vol. 64, No. 4, 1978, p. 691-695.

Research output: Contribution to journalArticle

Spiegel, Allen M. ; Greene, M. ; Magrath, I. ; Balow, J. ; Marx, S. ; Aurbach, G. D. / Hypercalcemia with suppressed parathyroid hormone in Burkitt's lymphoma. In: The American journal of medicine. 1978 ; Vol. 64, No. 4. pp. 691-695.
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