Hydraulic model of the cerebrovascular bed

An aid to understanding the volume-pressure test

M. Chopp, H. D. Portnoy, Craig A. Branch

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

A hydraulic model of the cerebrovascular bed is presented. The model consists of a Starling resistor in series with an upstream resistance. Volume-pressure tests were performed on the model by injecting fluid into the rigid shell of the Starling resistor. An exponential pressure response to the increase in fluid volume was observed, which supports the hypothesis that the origin of the in vivo exponential pressure response to a transient increase in cerebrospinal fluid (CSF) volume can be attributed to compression of the cerebral vessels, most probably the veins. Mathematical expressions for the dependence of pressure on volume change were derived from the model and applied to in vivo volume-pressure data. The correlation between the model and in vivo experiments suggests that the CSF pressure is coupled to cerebral venous pressure and that the volume-pressure test is an indirect measure of the cerebral venous volume and is not a measure of intracranial elastance. The physical basis for the volume-pressure test is clarified, and expressions are derived to improve the utility of the test.

Original languageEnglish (US)
Pages (from-to)5-11
Number of pages7
JournalNeurosurgery
Volume13
Issue number1
StatePublished - 1983
Externally publishedYes

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Pressure
Starlings
Cerebrospinal Fluid Pressure
Venous Pressure
Cerebrospinal Fluid
Veins

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Hydraulic model of the cerebrovascular bed : An aid to understanding the volume-pressure test. / Chopp, M.; Portnoy, H. D.; Branch, Craig A.

In: Neurosurgery, Vol. 13, No. 1, 1983, p. 5-11.

Research output: Contribution to journalArticle

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