@inbook{498d658bea7543299fda3d75eedb41ed,
title = "{"}Humanized{"} HLA transgenic NOD mice to identify pancreatic β cell autoantigens of potential clinical relevance to type 1 diabetes",
abstract = "The mechanistic basis bywhich the H2g7 major histocompatibility complex (MHC) provides the primary risk factor for the development of T cell-mediated autoimmune type 1 diabetes (T1D) in non-obese diabetic (NOD) mice involves contributions not only fromthe unusual Ag7 class II molecule, but also from the more common Kd and/or Db class I variants it encodes. Similarly, transgenic studies in NOD mice have confirmed the possibility first suggested in association studies that in the proper genetic context the common human HLA-A2.1 class I variant can mediate diabetogenic CD8 T cell responses. T1D continues to develop in a further refined NOD stock that expresses human HLA-A2.1, but no murine class I molecules (designated NOD.β2m-.HHD). Islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) is an important antigenic target of diabetogenic CD8 cells in standard NOD mice. Three IGRP-derived peptides have also been identified that are presented by human HLA-A2.1 molecules to diabetogenic CD8 T cells in NOD.β2m-.HHD mice. At least one of these IGRP peptides (265-273) can also be the target of autoreactive CD8 T cells in HLA-A2.1-expressing human T1D patients. Studies are currently under way to determine whether HLA-A2.1-restricted IGRP peptides can be used in a tolerance-inducing protocol that inhibits T1D development in NOD. β2m-.HHD mice. If so, this knowledge could ultimately lead to the development of a similar T1D prevention protocol in humans.",
keywords = "Autoimmunity, Diabetes, Humanized mice, T cells",
author = "Serreze, {David V.} and Marron, {Michele P.} and DiLorenzo, {Teresa P.}",
year = "2007",
month = apr,
doi = "10.1196/annals.1394.019",
language = "English (US)",
isbn = "1573316784",
series = "Annals of the New York Academy of Sciences",
publisher = "Blackwell Publishing Inc.",
pages = "103--111",
booktitle = "How Do We Best Employ Animal Models for Type 1 Diabetesand Multiple Sclerosis",
}