Human xenografts are not rejected in a naturally occurring immunodeficient porcine line: A human tumor model in pigs

Matthew T. Basel, Sivasai Balivada, Amanda P. Beck, Maureen A. Kerrigan, Marla M. Pyle, Jack C.M. Dekkers, Carol R. Wyatt, Robert R.R. Rowland, David E. Anderson, Stefan H. Bossmann, Deryl L. Troyer

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Animal models for cancer therapy are invaluable for preclinical testing of potential cancer treatments, however, therapies tested in such models often fail to translate into clinical settings. Therefore, a better preclinical model for cancer treatment testing is needed. Here we demonstrate that an immunodeficient line of pigs can host and support the growth of xenografted human tumors and has the potential to be an effective animal model for cancer therapy. Wild-type and immunodeficient pigs were injected subcutaneously in the left ear with human melanoma cells (A375SM cells) and in the right ear with human pancreatic carcinoma cells (PANC-1). All immunodeficient pigs developed tumors that were verified by histology and immunohistochemistry. Nonaffected littermates did not develop tumors. Immunodeficient pigs, which do not reject xenografted human tumors, have the potential to become an extremely useful animal model for cancer therapy because of their similarity in size, anatomy, and physiology to humans.

Original languageEnglish (US)
Pages (from-to)63-68
Number of pages6
JournalBioResearch Open Access
Volume1
Issue number2
DOIs
StatePublished - 2012

Keywords

  • Immunodeficient swine
  • Large-animal cancer model
  • Melanoma
  • Pancreatic carcinoma
  • Xenografts

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Human xenografts are not rejected in a naturally occurring immunodeficient porcine line: A human tumor model in pigs'. Together they form a unique fingerprint.

  • Cite this

    Basel, M. T., Balivada, S., Beck, A. P., Kerrigan, M. A., Pyle, M. M., Dekkers, J. C. M., Wyatt, C. R., Rowland, R. R. R., Anderson, D. E., Bossmann, S. H., & Troyer, D. L. (2012). Human xenografts are not rejected in a naturally occurring immunodeficient porcine line: A human tumor model in pigs. BioResearch Open Access, 1(2), 63-68. https://doi.org/10.1089/biores.2012.9902