Human type II collagen gene (COL2A1) assigned to chromosome 12q13.1-q13.2 by in situ hybridization with biotinylated DNA probe

Ei ichi Takahashi, Tada aki Hori, Jeanne B. Lawrence, John McNeil, Robert H. Singer, Peter O'Connell, Mark Leppert, Ray White

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

We have made a regional assignment of the type II collagen gene (COL2A1) on human chromosome 12 by means of an in situ hybridization technique with a biotinylated DNA probe. The precise localization of the signal was mapped to the band 12q13.1-q13.2. This result was in agreement with the previous mapping by isotopic in situ hybridization technique (12q13.1-q13.2), but not with the result of Southern hybridization analysis using somatic cell hybrids (12q14.3).

Original languageEnglish (US)
Pages (from-to)307-311
Number of pages5
JournalThe Japanese Journal of Human Genetics
Volume34
Issue number4
DOIs
StatePublished - Dec 1 1989
Externally publishedYes

Keywords

  • COL2A1 and chromosome 12
  • chromosome mapping
  • nonisotopic in situ hybridization

ASJC Scopus subject areas

  • Genetics(clinical)

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