Human T-cell lymphotropic virus type I (HTLV-I) antibodies in pre-diagnostic serum of patients with familial adult T-cell leukemia/lymphoma (ATL)

A. M Y Nomura, E. T. Yanagihara, W. A. Blattner, G. Y F Ho, M. S. Ina masu, R. K. Severson, J. M. Nakamura

Research output: Contribution to journalArticle

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Abstract

In a study of 7498 American men of Japanese ancestry in Hawaii, 26 incident cases of leukemia or non-Hodgkin's lymphoma were identified after a follow-up period of 19 years. Two of the cases, who were brothers, were diagnosed with adult T-cell leukemia/lymphoma (ATL). Both of these brothers had human T-cell lymphotropic virus type I (HTLV-I) antibodies in their stored serum which were obtained 4 and 18 years before diagnosis. None of the 24 patients with other hematologic malignancies or the 26 matched controls were HTLV-I antibody positive. This finding lends further support for a role of HTLV-I in the etiology of adult T-cell leukemia/lymphoma.

Original languageEnglish (US)
Pages (from-to)169-176
Number of pages8
JournalHematological Oncology
Volume8
Issue number3
DOIs
StatePublished - 1990
Externally publishedYes

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Adult T Cell Leukemia Lymphoma
Viruses
T-Lymphocytes
Antibodies
Siblings
Serum
Hematologic Neoplasms
Non-Hodgkin's Lymphoma
Leukemia

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Nomura, A. M. Y., Yanagihara, E. T., Blattner, W. A., Ho, G. Y. F., Ina masu, M. S., Severson, R. K., & Nakamura, J. M. (1990). Human T-cell lymphotropic virus type I (HTLV-I) antibodies in pre-diagnostic serum of patients with familial adult T-cell leukemia/lymphoma (ATL). Hematological Oncology, 8(3), 169-176. https://doi.org/10.1002/hon.2900080308

Human T-cell lymphotropic virus type I (HTLV-I) antibodies in pre-diagnostic serum of patients with familial adult T-cell leukemia/lymphoma (ATL). / Nomura, A. M Y; Yanagihara, E. T.; Blattner, W. A.; Ho, G. Y F; Ina masu, M. S.; Severson, R. K.; Nakamura, J. M.

In: Hematological Oncology, Vol. 8, No. 3, 1990, p. 169-176.

Research output: Contribution to journalArticle

Nomura, A. M Y ; Yanagihara, E. T. ; Blattner, W. A. ; Ho, G. Y F ; Ina masu, M. S. ; Severson, R. K. ; Nakamura, J. M. / Human T-cell lymphotropic virus type I (HTLV-I) antibodies in pre-diagnostic serum of patients with familial adult T-cell leukemia/lymphoma (ATL). In: Hematological Oncology. 1990 ; Vol. 8, No. 3. pp. 169-176.
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AU - Blattner, W. A.

AU - Ho, G. Y F

AU - Ina masu, M. S.

AU - Severson, R. K.

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