Human T‐cell lymphotropic virus type I (HTLV‐I) antibodies in pre‐diagnostic serum of patients with familial adult T‐cell leukemia/lymphoma (ATL)

Abraham M.Y. Nomura; Eugene T. Yanagihara; William A. Blattner; Gloria Y.F. Ho; Melvin S. Inamasu; Richard K. Severson; Jeffrey M. Nakamura

doi:10.1002/hon.2900080308

Human T‐cell lymphotropic virus type I (HTLV‐I) antibodies in pre‐diagnostic serum of patients with familial adult T‐cell leukemia/lymphoma (ATL)

Abraham M.Y. Nomura, Eugene T. Yanagihara, William A. Blattner, Gloria Y.F. Ho, Melvin S. Inamasu, Richard K. Severson, Jeffrey M. Nakamura

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

In a study of 7498 American men of Japanese ancestry in Hawaii, 26 incident cases of leukemia or non‐Hodgkin's lymphoma were identified after a follow‐up period of 19 years. Two of the cases, who were brothers, were diagnosed with adult T‐cell leukemia/lymphoma (ATL). Both of these brothers had human T‐cell lymphotropic virus type I (HTLV‐I) antibodies in their stored serum which were obtained 4 and 18 years before diagnosis. None of the 24 patients with other hematologic malignancies or the 26 matched controls were HTLV‐I antibody positive. This finding lends further support for a role of HTLV‐I in the etiology of adult T‐cell leukemia/lymphoma.

Original language	English (US)
Pages (from-to)	169-176
Number of pages	8
Journal	Hematological Oncology
Volume	8
Issue number	3
DOIs	https://doi.org/10.1002/hon.2900080308
State	Published - 1990
Externally published	Yes

Keywords

Familial ATL
HTLV‐I Antibodies
Leukemia
Lymphoma

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/hon.2900080308

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title = "Human T‐cell lymphotropic virus type I (HTLV‐I) antibodies in pre‐diagnostic serum of patients with familial adult T‐cell leukemia/lymphoma (ATL)",

abstract = "In a study of 7498 American men of Japanese ancestry in Hawaii, 26 incident cases of leukemia or non‐Hodgkin's lymphoma were identified after a follow‐up period of 19 years. Two of the cases, who were brothers, were diagnosed with adult T‐cell leukemia/lymphoma (ATL). Both of these brothers had human T‐cell lymphotropic virus type I (HTLV‐I) antibodies in their stored serum which were obtained 4 and 18 years before diagnosis. None of the 24 patients with other hematologic malignancies or the 26 matched controls were HTLV‐I antibody positive. This finding lends further support for a role of HTLV‐I in the etiology of adult T‐cell leukemia/lymphoma.",

keywords = "Familial ATL, HTLV‐I Antibodies, Leukemia, Lymphoma",

author = "Nomura, {Abraham M.Y.} and Yanagihara, {Eugene T.} and Blattner, {William A.} and Ho, {Gloria Y.F.} and Inamasu, {Melvin S.} and Severson, {Richard K.} and Nakamura, {Jeffrey M.}",

year = "1990",

doi = "10.1002/hon.2900080308",

language = "English (US)",

volume = "8",

pages = "169--176",

journal = "Hematological Oncology",

issn = "0278-0232",

publisher = "John Wiley and Sons Ltd",

number = "3",

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T1 - Human T‐cell lymphotropic virus type I (HTLV‐I) antibodies in pre‐diagnostic serum of patients with familial adult T‐cell leukemia/lymphoma (ATL)

AU - Nomura, Abraham M.Y.

AU - Yanagihara, Eugene T.

AU - Blattner, William A.

AU - Ho, Gloria Y.F.

AU - Inamasu, Melvin S.

AU - Severson, Richard K.

AU - Nakamura, Jeffrey M.

PY - 1990

Y1 - 1990

N2 - In a study of 7498 American men of Japanese ancestry in Hawaii, 26 incident cases of leukemia or non‐Hodgkin's lymphoma were identified after a follow‐up period of 19 years. Two of the cases, who were brothers, were diagnosed with adult T‐cell leukemia/lymphoma (ATL). Both of these brothers had human T‐cell lymphotropic virus type I (HTLV‐I) antibodies in their stored serum which were obtained 4 and 18 years before diagnosis. None of the 24 patients with other hematologic malignancies or the 26 matched controls were HTLV‐I antibody positive. This finding lends further support for a role of HTLV‐I in the etiology of adult T‐cell leukemia/lymphoma.

AB - In a study of 7498 American men of Japanese ancestry in Hawaii, 26 incident cases of leukemia or non‐Hodgkin's lymphoma were identified after a follow‐up period of 19 years. Two of the cases, who were brothers, were diagnosed with adult T‐cell leukemia/lymphoma (ATL). Both of these brothers had human T‐cell lymphotropic virus type I (HTLV‐I) antibodies in their stored serum which were obtained 4 and 18 years before diagnosis. None of the 24 patients with other hematologic malignancies or the 26 matched controls were HTLV‐I antibody positive. This finding lends further support for a role of HTLV‐I in the etiology of adult T‐cell leukemia/lymphoma.

KW - Familial ATL

KW - HTLV‐I Antibodies

KW - Leukemia

KW - Lymphoma

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Human T‐cell lymphotropic virus type I (HTLV‐I) antibodies in pre‐diagnostic serum of patients with familial adult T‐cell leukemia/lymphoma (ATL)

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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