Human serum does contain a high molecular weight hepatocyte growth factor: Studies pre- and post-hepatic resection

R. Clare Selden, Johnstone Helen Darby, S. Gupta, H. J.F. Hodgson

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

Levels of a high molecular weight hepatotrophin were measured in human serum taken from patients before and 24 hours after undergoing major hepatic resection. In in-vitro rat hepatocyte cultures a 'hepatotrophin' enriched fraction of human serum induced the incorporation of tritiated thymidine into DNA in both pre and post-operative patients. Levels after hepatic resection were 2-3 fold higher than those achieved at the same protein concentration before operation in the same patient. The hepatotrophic factor had an apparent molecular weight of approximately 150,000 daltons, and was an anionic protein.

Original languageEnglish (US)
Pages (from-to)361-366
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume139
Issue number1
DOIs
StatePublished - Aug 29 1986
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Human serum does contain a high molecular weight hepatocyte growth factor: Studies pre- and post-hepatic resection'. Together they form a unique fingerprint.

  • Cite this