TY - JOUR
T1 - Human serum does contain a high molecular weight hepatocyte growth factor
T2 - Studies pre- and post-hepatic resection
AU - Clare Selden, R.
AU - Darby, Johnstone Helen
AU - Gupta, S.
AU - Hodgson, H. J.F.
PY - 1986/8/29
Y1 - 1986/8/29
N2 - Levels of a high molecular weight hepatotrophin were measured in human serum taken from patients before and 24 hours after undergoing major hepatic resection. In in-vitro rat hepatocyte cultures a 'hepatotrophin' enriched fraction of human serum induced the incorporation of tritiated thymidine into DNA in both pre and post-operative patients. Levels after hepatic resection were 2-3 fold higher than those achieved at the same protein concentration before operation in the same patient. The hepatotrophic factor had an apparent molecular weight of approximately 150,000 daltons, and was an anionic protein.
AB - Levels of a high molecular weight hepatotrophin were measured in human serum taken from patients before and 24 hours after undergoing major hepatic resection. In in-vitro rat hepatocyte cultures a 'hepatotrophin' enriched fraction of human serum induced the incorporation of tritiated thymidine into DNA in both pre and post-operative patients. Levels after hepatic resection were 2-3 fold higher than those achieved at the same protein concentration before operation in the same patient. The hepatotrophic factor had an apparent molecular weight of approximately 150,000 daltons, and was an anionic protein.
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U2 - 10.1016/S0006-291X(86)80122-X
DO - 10.1016/S0006-291X(86)80122-X
M3 - Article
C2 - 3767961
AN - SCOPUS:0022479427
SN - 0006-291X
VL - 139
SP - 361
EP - 366
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1
ER -