Levels of a high molecular weight hepatotrophin were measured in human serum taken from patients before and 24 hours after undergoing major hepatic resection. In in-vitro rat hepatocyte cultures a 'hepatotrophin' enriched fraction of human serum induced the incorporation of tritiated thymidine into DNA in both pre and post-operative patients. Levels after hepatic resection were 2-3 fold higher than those achieved at the same protein concentration before operation in the same patient. The hepatotrophic factor had an apparent molecular weight of approximately 150,000 daltons, and was an anionic protein.
|Original language||English (US)|
|Number of pages||6|
|Journal||Biochemical and Biophysical Research Communications|
|State||Published - Aug 29 1986|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology