Human seizures couple across spatial scales through travelling wave dynamics

L. E. Martinet, G. Fiddyment, J. R. Madsen, Emad N. Eskandar, W. Truccolo, U. T. Eden, S. S. Cash, M. A. Kramer

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Epilepsy-the propensity toward recurrent, unprovoked seizures-is a devastating disease affecting 65 million people worldwide. Understanding and treating this disease remains a challenge, as seizures manifest through mechanisms and features that span spatial and temporal scales. Here we address this challenge through the analysis and modelling of human brain voltage activity recorded simultaneously across microscopic and macroscopic spatial scales. We show that during seizure large-scale neural populations spanning centimetres of cortex coordinate with small neural groups spanning cortical columns, and provide evidence that rapidly propagating waves of activity underlie this increased inter-scale coupling. We develop a corresponding computational model to propose specific mechanisms-namely, the effects of an increased extracellular potassium concentration diffusing in space-that support the observed spatiotemporal dynamics. Understanding the multi-scale, spatiotemporal dynamics of human seizures-and connecting these dynamics to specific biological mechanisms-promises new insights to treat this devastating disease.

Original languageEnglish (US)
Article number14896
JournalNature Communications
Volume8
DOIs
StatePublished - Apr 4 2017
Externally publishedYes

Fingerprint

seizures
traveling waves
Seizures
Brain
epilepsy
Potassium
cortexes
Epilepsy
Electric potential
brain
potassium
Population
electric potential

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Martinet, L. E., Fiddyment, G., Madsen, J. R., Eskandar, E. N., Truccolo, W., Eden, U. T., ... Kramer, M. A. (2017). Human seizures couple across spatial scales through travelling wave dynamics. Nature Communications, 8, [14896]. https://doi.org/10.1038/ncomms14896

Human seizures couple across spatial scales through travelling wave dynamics. / Martinet, L. E.; Fiddyment, G.; Madsen, J. R.; Eskandar, Emad N.; Truccolo, W.; Eden, U. T.; Cash, S. S.; Kramer, M. A.

In: Nature Communications, Vol. 8, 14896, 04.04.2017.

Research output: Contribution to journalArticle

Martinet, LE, Fiddyment, G, Madsen, JR, Eskandar, EN, Truccolo, W, Eden, UT, Cash, SS & Kramer, MA 2017, 'Human seizures couple across spatial scales through travelling wave dynamics', Nature Communications, vol. 8, 14896. https://doi.org/10.1038/ncomms14896
Martinet, L. E. ; Fiddyment, G. ; Madsen, J. R. ; Eskandar, Emad N. ; Truccolo, W. ; Eden, U. T. ; Cash, S. S. ; Kramer, M. A. / Human seizures couple across spatial scales through travelling wave dynamics. In: Nature Communications. 2017 ; Vol. 8.
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