Human Schlafen 5 (SLFN5) is a regulator of motility and invasiveness of renal cell carcinoma cells

Antonella Sassano, Evangelos Mavrommatis, Ahmet Dirim Arslan, Barbara Kroczynska, Elspeth M. Beauchamp, Satya Khuon, Ten Leong Chew, Kathleen J. Green, Hidayatullah G. Munshi, Amit K. Verma, Leonidas C. Platanias

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Abstract

We provide evidence that human SLFN5, an interferon (IFN)-inducible member of the Schlafen (SLFN) family of proteins, exhibits key roles in controlling motility and invasiveness of renal cell carcinoma (RCC) cells. Our studies define the mechanism by which this occurs, demonstrating that SLFN5 negatively controls expression of the matrix metalloproteinase 1 gene (MMP-1), MMP-13, and several other genes involved in the control of malignant cell motility. Importantly, our data establish that SLFN5 expression correlates with a better overall survival in a large cohort of patients with RCC. The inverse relationship between SLFN5 expression and RCC aggressiveness raises the possibility of developing unique therapeutic approaches in the treatment of RCC, by modulating SLFN5 expression.

Original languageEnglish (US)
Pages (from-to)2684-2698
Number of pages15
JournalMolecular and cellular biology
Volume35
Issue number15
DOIs
Publication statusPublished - Jan 1 2015

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ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Sassano, A., Mavrommatis, E., Arslan, A. D., Kroczynska, B., Beauchamp, E. M., Khuon, S., ... Platanias, L. C. (2015). Human Schlafen 5 (SLFN5) is a regulator of motility and invasiveness of renal cell carcinoma cells. Molecular and cellular biology, 35(15), 2684-2698. https://doi.org/10.1128/MCB.00019-15