Human papillomavirus types 16 and 33, herpes simplex virus type 2 and other risk factors for cervical cancer in sichuan province, china

Hongqi Peng, Shanling Liu, Valerie Mann, Thomas Rohan, William Rawls

Research output: Contribution to journalArticle

66 Scopus citations


Cancer of the cervix is relatively common in China, but has been investigated epidemiologically in only a few studies. In the hospital‐based case‐control study reported here, we investigated the role of various lifestyle and dietary factors, as well as infection with human papillomavirus (HPV) types 16 and 33 and herpes simplex virus type 2 in the aetiology of invasive cervical cancer. The study was conducted in Sichuan province, and involved 101 cases with histologically‐confirmed cervical cancer recruited from the gynaecological oncology clinic of the West China University Hospital, and 146 controls recruited from patients attending the gynaecology clinic of the same hospital. Risk of cervical cancer was greatly increased in association with infection with HPV 16/33, the adjusted odds ratio for those with evidence of infection being 32.9 (95% Cl 7.7‐141.1). In contrast, infection with HSV 2 was not associated with a significantly altered risk of cervical cancer. Indices of sexual history and of dietary habits also showed no association with risk of cervical cancer, while good personal and genital hygiene were associated with markedly reduced risk. Although the results of this study are consistent with a causal role for HPV in the aetiology of cervical cancer, bias or increased viral expression following malignant transformation cannot be excluded as explanations for the strong positive association.

Original languageEnglish (US)
Pages (from-to)711-716
Number of pages6
JournalInternational Journal of Cancer
Issue number5
Publication statusPublished - Mar 12 1991
Externally publishedYes


ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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