Human papillomavirus type 6a DNA in the lung carcinoma of a patient with recurrent laryngeal papillomatosis is characterized by a partial duplication

T. P. DiLorenzo, A. Tamsen, A. L. Abramson, B. M. Steinberg

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Abstract

Transcriptionally active human papillomavirus type 6a (HPV-6a) DNA was detected in a lung carcinoma of a patient with recurrent laryngeal papillomatosis. The carcinoma contained episomal HPV-6a genomes that had a duplication of the upstream regulatory region, the late region and a portion of the early region. HPV-6a genomes found in benign laryngeal papillomas from the same patient did not contain this duplication. A role for the mutant molecules in the pathogenesis of the malignancy is suggested.

Original languageEnglish (US)
Pages (from-to)423-428
Number of pages6
JournalJournal of General Virology
Volume73
Issue number2
DOIs
Publication statusPublished - Jan 1 1992

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ASJC Scopus subject areas

  • Virology

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