Abstract
Transcriptionally active human papillomavirus type 6a (HPV-6a) DNA was detected in a lung carcinoma of a patient with recurrent laryngeal papillomatosis. The carcinoma contained episomal HPV-6a genomes that had a duplication of the upstream regulatory region, the late region and a portion of the early region. HPV-6a genomes found in benign laryngeal papillomas from the same patient did not contain this duplication. A role for the mutant molecules in the pathogenesis of the malignancy is suggested.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 423-428 |
| Number of pages | 6 |
| Journal | Journal of General Virology |
| Volume | 73 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 1 1992 |
ASJC Scopus subject areas
- Virology
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DiLorenzo, T. P., Tamsen, A., Abramson, A. L., & Steinberg, B. M. (1992). Human papillomavirus type 6a DNA in the lung carcinoma of a patient with recurrent laryngeal papillomatosis is characterized by a partial duplication. Journal of General Virology, 73(2), 423-428. https://doi.org/10.1099/0022-1317-73-2-423