TY - JOUR
T1 - Human papillomavirus type 13 and pygmy chimpanzee papillomavirus type 1
T2 - comparison of the genome organizations
AU - Ranst, Marc van
AU - Fuse, Akira
AU - Fiten, Pierre
AU - Beuken, Erik
AU - Pfister, Herbert
AU - Burk, Robert D.
AU - Opdenakker, Ghislain
N1 - Funding Information:
This research was supported by grants from the Cancer Fund of the General Savings and Retirement Fund (ASLKfCGER) and in part by NIH Grant 5P30 CA-1 3330. M.V.R. was supported by a fellowship from the Belgian American Educational Foundation and from the D.
PY - 1992/10
Y1 - 1992/10
N2 - Human papillomavirus type 13 (H PV-13) is associated with oral focal epithelial hyperplasia (FEH) in humans. A recent epidemic of a FEH-like disease in a pygmy chimpanzee (Pan paniscus) colony allowed us to clone a novel papillomavirus genome. To assess the homology between HPV-13 and the pygmy chimpanzee papillomavirus type 1 (PCPV-1), the complete nucleotide sequences of both FEH-related viruses were determined. In both viruses, all eight major open reading frames were located on one strand and the genomic organization was similar to that of other mucosal papillomaviruses. The genomes of PCPV-1 and HPV-13 showed extensive overall sequence homology (85%). They could be classified, using phylogenetic analysis, together with HPV types 6, 11, 43, and 44 in a group associated with benign orogenital lesions. These data indicate that two phylogenetically related papillomavinuses can elicit similar pathology in different primate host species, reflecting viral genomic similarities.
AB - Human papillomavirus type 13 (H PV-13) is associated with oral focal epithelial hyperplasia (FEH) in humans. A recent epidemic of a FEH-like disease in a pygmy chimpanzee (Pan paniscus) colony allowed us to clone a novel papillomavirus genome. To assess the homology between HPV-13 and the pygmy chimpanzee papillomavirus type 1 (PCPV-1), the complete nucleotide sequences of both FEH-related viruses were determined. In both viruses, all eight major open reading frames were located on one strand and the genomic organization was similar to that of other mucosal papillomaviruses. The genomes of PCPV-1 and HPV-13 showed extensive overall sequence homology (85%). They could be classified, using phylogenetic analysis, together with HPV types 6, 11, 43, and 44 in a group associated with benign orogenital lesions. These data indicate that two phylogenetically related papillomavinuses can elicit similar pathology in different primate host species, reflecting viral genomic similarities.
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U2 - 10.1016/0042-6822(92)90896-W
DO - 10.1016/0042-6822(92)90896-W
M3 - Article
C2 - 1325697
AN - SCOPUS:0026664621
SN - 0042-6822
VL - 190
SP - 587
EP - 596
JO - Virology
JF - Virology
IS - 2
ER -