Human papillomavirus type 13 and pygmy chimpanzee papillomavirus type 1

comparison of the genome organizations

Marc van Ranst, Akira Fuse, Pierre Fiten, Erik Beuken, Herbert Pfister, Robert D. Burk, Ghislain Opdenakker

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Human papillomavirus type 13 (H PV-13) is associated with oral focal epithelial hyperplasia (FEH) in humans. A recent epidemic of a FEH-like disease in a pygmy chimpanzee (Pan paniscus) colony allowed us to clone a novel papillomavirus genome. To assess the homology between HPV-13 and the pygmy chimpanzee papillomavirus type 1 (PCPV-1), the complete nucleotide sequences of both FEH-related viruses were determined. In both viruses, all eight major open reading frames were located on one strand and the genomic organization was similar to that of other mucosal papillomaviruses. The genomes of PCPV-1 and HPV-13 showed extensive overall sequence homology (85%). They could be classified, using phylogenetic analysis, together with HPV types 6, 11, 43, and 44 in a group associated with benign orogenital lesions. These data indicate that two phylogenetically related papillomavinuses can elicit similar pathology in different primate host species, reflecting viral genomic similarities.

Original languageEnglish (US)
Pages (from-to)587-596
Number of pages10
JournalVirology
Volume190
Issue number2
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Pan paniscus
Focal Epithelial Hyperplasia
Genome
Human papillomavirus 11
Human papillomavirus 6
Viruses
Sequence Homology
Primates
Open Reading Frames
Clone Cells
Pathology

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Human papillomavirus type 13 and pygmy chimpanzee papillomavirus type 1 : comparison of the genome organizations. / Ranst, Marc van; Fuse, Akira; Fiten, Pierre; Beuken, Erik; Pfister, Herbert; Burk, Robert D.; Opdenakker, Ghislain.

In: Virology, Vol. 190, No. 2, 1992, p. 587-596.

Research output: Contribution to journalArticle

Ranst, Marc van ; Fuse, Akira ; Fiten, Pierre ; Beuken, Erik ; Pfister, Herbert ; Burk, Robert D. ; Opdenakker, Ghislain. / Human papillomavirus type 13 and pygmy chimpanzee papillomavirus type 1 : comparison of the genome organizations. In: Virology. 1992 ; Vol. 190, No. 2. pp. 587-596.
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