Human papillomavirus prevalence in women who have and have not undergone hysterectomies

Philip E. Castle, Mark Schiffman, Andrew G. Glass, Brenda B. Rush, David R. Scott, Sholom Wacholder, Anne Dunn, Robert D. Burk

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

We compared human papillomavirus (HPV) prevalence in an age-stratified random sample of women who have undergone a hysterectomy (WH) (n = 573) with the HPV prevalence in age-matched women with intact cervices (women who have not undergone a hysterectomy [WNH]) (n = 581) participating in a study at Kaiser Permanente in Portland, Oregon. Testing cervicovaginal lavage fluids for >40 HPV genotypes using an MY09/11 L1 consensus primer polymerase chain reaction method, we found no statistical differences in the prevalence of HPV (16% for WNH vs. 13.9% for WH) or carcinogenic HPV (6.5% for WNH vs. 4.5% for WH) between the 2 groups of women. Although WH have a similar prevalence of carcinogenic HPV infection, compared with WNH without a cervix, they have minimal risk of HPV-induced cancer and are unlikely to benefit from HPV testing.

Original languageEnglish (US)
Pages (from-to)1702-1705
Number of pages4
JournalJournal of Infectious Diseases
Volume194
Issue number12
DOIs
StatePublished - Dec 15 2006

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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