Human papillomavirus prevalence in women who have and have not undergone hysterectomies

Philip E. Castle, Mark Schiffman, Andrew G. Glass, Brenda B. Rush, David R. Scott, Sholom Wacholder, Anne Dunn, Robert D. Burk

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We compared human papillomavirus (HPV) prevalence in an age-stratified random sample of women who have undergone a hysterectomy (WH) (n = 573) with the HPV prevalence in age-matched women with intact cervices (women who have not undergone a hysterectomy [WNH]) (n = 581) participating in a study at Kaiser Permanente in Portland, Oregon. Testing cervicovaginal lavage fluids for >40 HPV genotypes using an MY09/11 L1 consensus primer polymerase chain reaction method, we found no statistical differences in the prevalence of HPV (16% for WNH vs. 13.9% for WH) or carcinogenic HPV (6.5% for WNH vs. 4.5% for WH) between the 2 groups of women. Although WH have a similar prevalence of carcinogenic HPV infection, compared with WNH without a cervix, they have minimal risk of HPV-induced cancer and are unlikely to benefit from HPV testing.

Original languageEnglish (US)
Pages (from-to)1702-1705
Number of pages4
JournalJournal of Infectious Diseases
Volume194
Issue number12
DOIs
StatePublished - Dec 15 2006

Fingerprint

Hysterectomy
Cervix Uteri
Papillomavirus Infections
Human papillomavirus 16
Therapeutic Irrigation
Genotype
Polymerase Chain Reaction
Neoplasms

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Human papillomavirus prevalence in women who have and have not undergone hysterectomies. / Castle, Philip E.; Schiffman, Mark; Glass, Andrew G.; Rush, Brenda B.; Scott, David R.; Wacholder, Sholom; Dunn, Anne; Burk, Robert D.

In: Journal of Infectious Diseases, Vol. 194, No. 12, 15.12.2006, p. 1702-1705.

Research output: Contribution to journalArticle

Castle, PE, Schiffman, M, Glass, AG, Rush, BB, Scott, DR, Wacholder, S, Dunn, A & Burk, RD 2006, 'Human papillomavirus prevalence in women who have and have not undergone hysterectomies', Journal of Infectious Diseases, vol. 194, no. 12, pp. 1702-1705. https://doi.org/10.1086/509511
Castle, Philip E. ; Schiffman, Mark ; Glass, Andrew G. ; Rush, Brenda B. ; Scott, David R. ; Wacholder, Sholom ; Dunn, Anne ; Burk, Robert D. / Human papillomavirus prevalence in women who have and have not undergone hysterectomies. In: Journal of Infectious Diseases. 2006 ; Vol. 194, No. 12. pp. 1702-1705.
@article{99f1d0f932e54b6e9fa22387cbb490cf,
title = "Human papillomavirus prevalence in women who have and have not undergone hysterectomies",
abstract = "We compared human papillomavirus (HPV) prevalence in an age-stratified random sample of women who have undergone a hysterectomy (WH) (n = 573) with the HPV prevalence in age-matched women with intact cervices (women who have not undergone a hysterectomy [WNH]) (n = 581) participating in a study at Kaiser Permanente in Portland, Oregon. Testing cervicovaginal lavage fluids for >40 HPV genotypes using an MY09/11 L1 consensus primer polymerase chain reaction method, we found no statistical differences in the prevalence of HPV (16{\%} for WNH vs. 13.9{\%} for WH) or carcinogenic HPV (6.5{\%} for WNH vs. 4.5{\%} for WH) between the 2 groups of women. Although WH have a similar prevalence of carcinogenic HPV infection, compared with WNH without a cervix, they have minimal risk of HPV-induced cancer and are unlikely to benefit from HPV testing.",
author = "Castle, {Philip E.} and Mark Schiffman and Glass, {Andrew G.} and Rush, {Brenda B.} and Scott, {David R.} and Sholom Wacholder and Anne Dunn and Burk, {Robert D.}",
year = "2006",
month = "12",
day = "15",
doi = "10.1086/509511",
language = "English (US)",
volume = "194",
pages = "1702--1705",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "12",

}

TY - JOUR

T1 - Human papillomavirus prevalence in women who have and have not undergone hysterectomies

AU - Castle, Philip E.

AU - Schiffman, Mark

AU - Glass, Andrew G.

AU - Rush, Brenda B.

AU - Scott, David R.

AU - Wacholder, Sholom

AU - Dunn, Anne

AU - Burk, Robert D.

PY - 2006/12/15

Y1 - 2006/12/15

N2 - We compared human papillomavirus (HPV) prevalence in an age-stratified random sample of women who have undergone a hysterectomy (WH) (n = 573) with the HPV prevalence in age-matched women with intact cervices (women who have not undergone a hysterectomy [WNH]) (n = 581) participating in a study at Kaiser Permanente in Portland, Oregon. Testing cervicovaginal lavage fluids for >40 HPV genotypes using an MY09/11 L1 consensus primer polymerase chain reaction method, we found no statistical differences in the prevalence of HPV (16% for WNH vs. 13.9% for WH) or carcinogenic HPV (6.5% for WNH vs. 4.5% for WH) between the 2 groups of women. Although WH have a similar prevalence of carcinogenic HPV infection, compared with WNH without a cervix, they have minimal risk of HPV-induced cancer and are unlikely to benefit from HPV testing.

AB - We compared human papillomavirus (HPV) prevalence in an age-stratified random sample of women who have undergone a hysterectomy (WH) (n = 573) with the HPV prevalence in age-matched women with intact cervices (women who have not undergone a hysterectomy [WNH]) (n = 581) participating in a study at Kaiser Permanente in Portland, Oregon. Testing cervicovaginal lavage fluids for >40 HPV genotypes using an MY09/11 L1 consensus primer polymerase chain reaction method, we found no statistical differences in the prevalence of HPV (16% for WNH vs. 13.9% for WH) or carcinogenic HPV (6.5% for WNH vs. 4.5% for WH) between the 2 groups of women. Although WH have a similar prevalence of carcinogenic HPV infection, compared with WNH without a cervix, they have minimal risk of HPV-induced cancer and are unlikely to benefit from HPV testing.

UR - http://www.scopus.com/inward/record.url?scp=33845416183&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33845416183&partnerID=8YFLogxK

U2 - 10.1086/509511

DO - 10.1086/509511

M3 - Article

C2 - 17109342

AN - SCOPUS:33845416183

VL - 194

SP - 1702

EP - 1705

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 12

ER -