Human papillomavirus prevalence in women who have and have not undergone hysterectomies

Philip E. Castle; Mark Schiffman; Andrew G. Glass; Brenda B. Rush; David R. Scott; Sholom Wacholder; Anne Dunn; Robert D. Burk

doi:10.1086/509511

Human papillomavirus prevalence in women who have and have not undergone hysterectomies

Philip E. Castle, Mark Schiffman, Andrew G. Glass, Brenda B. Rush, David R. Scott, Sholom Wacholder, Anne Dunn, Robert D. Burk

Pediatrics

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

We compared human papillomavirus (HPV) prevalence in an age-stratified random sample of women who have undergone a hysterectomy (WH) (n = 573) with the HPV prevalence in age-matched women with intact cervices (women who have not undergone a hysterectomy [WNH]) (n = 581) participating in a study at Kaiser Permanente in Portland, Oregon. Testing cervicovaginal lavage fluids for >40 HPV genotypes using an MY09/11 L1 consensus primer polymerase chain reaction method, we found no statistical differences in the prevalence of HPV (16% for WNH vs. 13.9% for WH) or carcinogenic HPV (6.5% for WNH vs. 4.5% for WH) between the 2 groups of women. Although WH have a similar prevalence of carcinogenic HPV infection, compared with WNH without a cervix, they have minimal risk of HPV-induced cancer and are unlikely to benefit from HPV testing.

Original language	English (US)
Pages (from-to)	1702-1705
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	194
Issue number	12
DOIs	https://doi.org/10.1086/509511
State	Published - Dec 15 2006

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1086/509511

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title = "Human papillomavirus prevalence in women who have and have not undergone hysterectomies",

abstract = "We compared human papillomavirus (HPV) prevalence in an age-stratified random sample of women who have undergone a hysterectomy (WH) (n = 573) with the HPV prevalence in age-matched women with intact cervices (women who have not undergone a hysterectomy [WNH]) (n = 581) participating in a study at Kaiser Permanente in Portland, Oregon. Testing cervicovaginal lavage fluids for >40 HPV genotypes using an MY09/11 L1 consensus primer polymerase chain reaction method, we found no statistical differences in the prevalence of HPV (16% for WNH vs. 13.9% for WH) or carcinogenic HPV (6.5% for WNH vs. 4.5% for WH) between the 2 groups of women. Although WH have a similar prevalence of carcinogenic HPV infection, compared with WNH without a cervix, they have minimal risk of HPV-induced cancer and are unlikely to benefit from HPV testing.",

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AU - Castle, Philip E.

AU - Schiffman, Mark

AU - Glass, Andrew G.

AU - Rush, Brenda B.

AU - Scott, David R.

AU - Wacholder, Sholom

AU - Dunn, Anne

AU - Burk, Robert D.

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Human papillomavirus prevalence in women who have and have not undergone hysterectomies

Abstract

ASJC Scopus subject areas

UN SDGs

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