Human Papillomavirus Prevalence in a Population of Women Living in Port-au-Prince and Leogane, Haiti

David K. Walmer, Paul S. Eder, Laura Bell, Hiam Salim, Lori Kobayashi, Jackie Ndirangu, Nicole Tinfo, Philip E. Castle

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Background:There have been no published studies of carcinogenic human papillomavirus (HPV)the necessary cause of cervical cancer in Haiti, a nation that has one of the greatest burdens of cervical cancer globally.Objective:Characterize prevalence of carcinogenic HPV and the prevalence of individual carcinogenic HPV genotypes in women with cervical precancer or cancer, cervical intraepithelial neoplasia grade 2 (CIN2) or more severe (CIN2+).Methods:Women (n=9,769; aged 25-60 years) were screened for carcinogenic HPV by Hybrid Capture 2 (HC2; Qiagen, Gaithersburg, MD). Carcinogenic HPV positives underwent colposcopy and visible lesions were biopsied. A subset of carcinogenic HPV positives was tested for individual HPV genotypes using a GP5+/6+ assay.Results:The prevalence of carcinogenic HPV was 19.0% (95% confidence interval: 18.4%-19.9%) and decreased with increasing age (ptrend < 0.001). Women with 3 or more sexual partners and who started sex before the age of 18 years had twice the age-adjusted prevalence of carcinogenic HPV of women with one partner and who started sex after the age of 21 (24.3% vs. 12.9%, respectively). HPV16 and HPV35 were the most common HPV genotypes detected in CIN2+ and more common in women with CIN2+ than those without CIN2+. HPV16 and/or HPV18 were detected in 21.0% of CIN2 (n = 42), 46.2% of CIN3 (n = 52), and 80% of cancers (n = 5).Conclusions:The prevalence of carcinogenic HPV in Haiti was much greater than the prevalence in other Latin American countries. High carcinogenic HPV prevalence and a lack of cervical cancer screening may explain the high burden of cervical cancer in Haiti.

Original languageEnglish (US)
Article numbere76110
JournalPloS one
Volume8
Issue number10
DOIs
StatePublished - Oct 3 2013

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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    Walmer, D. K., Eder, P. S., Bell, L., Salim, H., Kobayashi, L., Ndirangu, J., Tinfo, N., & Castle, P. E. (2013). Human Papillomavirus Prevalence in a Population of Women Living in Port-au-Prince and Leogane, Haiti. PloS one, 8(10), [e76110]. https://doi.org/10.1371/journal.pone.0076110