Human papillomavirus infections in laryngeal cancer

Mariela C. Torrente, Juan P. Rodrigo, Missak Haigentz, Frederik G. Dikkers, Alessandra Rinaldo, Robert P. Takes, Jan Olofsson, Alfio Ferlito

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

Although the association and clinical significance of human papillomavirus (HPV) infections with a subset of head and neck cancers, particularly for oropharyngeal carcinoma, has recently been well documented, the involvement of HPV in laryngeal cancer has been inadequately evaluated. Herein we review the currently known associations of HPV infections in diseases of the larynx and their potential for oncogenicity. Using several methods of detection, HPV DNA has been detected in benign (papillomatosis), indolent (verrucous carcinoma), and malignant (squamous cell carcinoma) lesions of the larynx. Consistent with the known oncogenic risk of HPV infections, common HPV types associated with laryngeal papillomatosis include low-risk HPV types 6 and 11, with high-risk HPV types 16 and 18 more commonly present in neoplastic lesions (verrucous carcinoma and squamous cell carcinoma). Although a broad range of prevalence has been noted in individual studies, approximately 25% of laryngeal squamous cell carcinomas harbor HPV infections on meta-analysis, with common involvement of high-risk HPV types 16 (highest frequency) and 18. Preliminary results suggest that these high-risk HPV infections seem to be biologically relevant in laryngeal carcinogenesis, manifested as having viral DNA integration in the cancer cell genome and increased expression of the p16 protein. Despite this knowledge, the clinical significance of these infections and the implications on disease prevention and treatment are unclear and require further investigation.

Original languageEnglish (US)
Pages (from-to)581-586
Number of pages6
JournalHead and Neck
Volume33
Issue number4
DOIs
StatePublished - Apr 2011

Fingerprint

Laryngeal Neoplasms
Papillomavirus Infections
Verrucous Carcinoma
Squamous Cell Carcinoma
Human papillomavirus 16
Laryngeal Diseases
Virus Integration
Human papillomavirus 11
Human papillomavirus 6
Human papillomavirus 18
Viral DNA
Papilloma
Head and Neck Neoplasms
Larynx
Meta-Analysis
Carcinogenesis
Genome
Carcinoma
DNA
Infection

Keywords

  • HPV
  • infection
  • larynx
  • papillomatosis
  • squamous cell carcinoma
  • verrucous carcinoma

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Torrente, M. C., Rodrigo, J. P., Haigentz, M., Dikkers, F. G., Rinaldo, A., Takes, R. P., ... Ferlito, A. (2011). Human papillomavirus infections in laryngeal cancer. Head and Neck, 33(4), 581-586. https://doi.org/10.1002/hed.21421

Human papillomavirus infections in laryngeal cancer. / Torrente, Mariela C.; Rodrigo, Juan P.; Haigentz, Missak; Dikkers, Frederik G.; Rinaldo, Alessandra; Takes, Robert P.; Olofsson, Jan; Ferlito, Alfio.

In: Head and Neck, Vol. 33, No. 4, 04.2011, p. 581-586.

Research output: Contribution to journalArticle

Torrente, MC, Rodrigo, JP, Haigentz, M, Dikkers, FG, Rinaldo, A, Takes, RP, Olofsson, J & Ferlito, A 2011, 'Human papillomavirus infections in laryngeal cancer', Head and Neck, vol. 33, no. 4, pp. 581-586. https://doi.org/10.1002/hed.21421
Torrente MC, Rodrigo JP, Haigentz M, Dikkers FG, Rinaldo A, Takes RP et al. Human papillomavirus infections in laryngeal cancer. Head and Neck. 2011 Apr;33(4):581-586. https://doi.org/10.1002/hed.21421
Torrente, Mariela C. ; Rodrigo, Juan P. ; Haigentz, Missak ; Dikkers, Frederik G. ; Rinaldo, Alessandra ; Takes, Robert P. ; Olofsson, Jan ; Ferlito, Alfio. / Human papillomavirus infections in laryngeal cancer. In: Head and Neck. 2011 ; Vol. 33, No. 4. pp. 581-586.
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