Human papillomavirus infection and cervical cytology in HIV-infected and HIV-Uninfected Rwandan women

Diljeet K. Singh, Kathryn Anastos, Donald R. Hoover, Robert D. Burk, Qiuhu Shi, Louis Ngendahayo, Eugene Mutimura, Antonio Cajigas, Venerand Bigirimani, Xiaotao Cai, Janvier Rwamwejo, Magalis Vuolo, Mardge Cohen, Philip E. Castle

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Abstract

Background. Data, on human papillomavirus (HPV) prevalence are essential for developing cost-effective cervical cancer prevention programs. Methods. In 2005,710 human immunodeficiency virus (HlV)-positive and. 226 HIV-negative Rwandan women enrolled in an observational prospective cohort study. Sociodemographic data, CD4 ' cell counts, and cervical specimens were obtained. Cervicovaginal lavage specimens were collected, from each woman and tested, for >40 HPV types by a polymerase chain reaction assay; HPV types 16,18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68 were considered primary carcinogenic HPV types. Results. The prevalence of HPV was higher in HIV-positive women than in HIV-negative women in all age groups. Among HIV-infected, women, 69% were positive for ≥1 HPV type, 46% for a carcinogenic HPV type, and. 10% for HPV-16. HPV prevalence peaked, at 75% in the HIV-positive women aged. 25-34 years and then declined with age to 37.5% in those ≥55 years old (P trend < .001 ). A significant trend, of higher prevalence of HPV and carcinogenic HPV with lower CD4 ' cell counts and increasing cytologic severity was seen among HIV-positive women. Conclusions. We found a higher prevalence of HPV infection in HIV-positive than in HIV-negative Rwandan women, and the prevalence of HPV and carcinogenic HPV infection decreased with age.

Original languageEnglish (US)
Pages (from-to)1851-1861
Number of pages11
JournalJournal of Infectious Diseases
Volume199
Issue number12
DOIs
StatePublished - Jun 5 2009

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Papillomavirus Infections
Cell Biology
HIV
Human papillomavirus 16
CD4 Lymphocyte Count
Human papillomavirus 18
Therapeutic Irrigation
Uterine Cervical Neoplasms
Cohort Studies
Age Groups
Prospective Studies

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy

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Human papillomavirus infection and cervical cytology in HIV-infected and HIV-Uninfected Rwandan women. / Singh, Diljeet K.; Anastos, Kathryn; Hoover, Donald R.; Burk, Robert D.; Shi, Qiuhu; Ngendahayo, Louis; Mutimura, Eugene; Cajigas, Antonio; Bigirimani, Venerand; Cai, Xiaotao; Rwamwejo, Janvier; Vuolo, Magalis; Cohen, Mardge; Castle, Philip E.

In: Journal of Infectious Diseases, Vol. 199, No. 12, 05.06.2009, p. 1851-1861.

Research output: Contribution to journalArticle

Singh, DK, Anastos, K, Hoover, DR, Burk, RD, Shi, Q, Ngendahayo, L, Mutimura, E, Cajigas, A, Bigirimani, V, Cai, X, Rwamwejo, J, Vuolo, M, Cohen, M & Castle, PE 2009, 'Human papillomavirus infection and cervical cytology in HIV-infected and HIV-Uninfected Rwandan women', Journal of Infectious Diseases, vol. 199, no. 12, pp. 1851-1861. https://doi.org/10.1086/599123
Singh, Diljeet K. ; Anastos, Kathryn ; Hoover, Donald R. ; Burk, Robert D. ; Shi, Qiuhu ; Ngendahayo, Louis ; Mutimura, Eugene ; Cajigas, Antonio ; Bigirimani, Venerand ; Cai, Xiaotao ; Rwamwejo, Janvier ; Vuolo, Magalis ; Cohen, Mardge ; Castle, Philip E. / Human papillomavirus infection and cervical cytology in HIV-infected and HIV-Uninfected Rwandan women. In: Journal of Infectious Diseases. 2009 ; Vol. 199, No. 12. pp. 1851-1861.
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abstract = "Background. Data, on human papillomavirus (HPV) prevalence are essential for developing cost-effective cervical cancer prevention programs. Methods. In 2005,710 human immunodeficiency virus (HlV)-positive and. 226 HIV-negative Rwandan women enrolled in an observational prospective cohort study. Sociodemographic data, CD4 ' cell counts, and cervical specimens were obtained. Cervicovaginal lavage specimens were collected, from each woman and tested, for >40 HPV types by a polymerase chain reaction assay; HPV types 16,18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68 were considered primary carcinogenic HPV types. Results. The prevalence of HPV was higher in HIV-positive women than in HIV-negative women in all age groups. Among HIV-infected, women, 69{\%} were positive for ≥1 HPV type, 46{\%} for a carcinogenic HPV type, and. 10{\%} for HPV-16. HPV prevalence peaked, at 75{\%} in the HIV-positive women aged. 25-34 years and then declined with age to 37.5{\%} in those ≥55 years old (P trend < .001 ). A significant trend, of higher prevalence of HPV and carcinogenic HPV with lower CD4 ' cell counts and increasing cytologic severity was seen among HIV-positive women. Conclusions. We found a higher prevalence of HPV infection in HIV-positive than in HIV-negative Rwandan women, and the prevalence of HPV and carcinogenic HPV infection decreased with age.",
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AU - Burk, Robert D.

AU - Shi, Qiuhu

AU - Ngendahayo, Louis

AU - Mutimura, Eugene

AU - Cajigas, Antonio

AU - Bigirimani, Venerand

AU - Cai, Xiaotao

AU - Rwamwejo, Janvier

AU - Vuolo, Magalis

AU - Cohen, Mardge

AU - Castle, Philip E.

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N2 - Background. Data, on human papillomavirus (HPV) prevalence are essential for developing cost-effective cervical cancer prevention programs. Methods. In 2005,710 human immunodeficiency virus (HlV)-positive and. 226 HIV-negative Rwandan women enrolled in an observational prospective cohort study. Sociodemographic data, CD4 ' cell counts, and cervical specimens were obtained. Cervicovaginal lavage specimens were collected, from each woman and tested, for >40 HPV types by a polymerase chain reaction assay; HPV types 16,18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68 were considered primary carcinogenic HPV types. Results. The prevalence of HPV was higher in HIV-positive women than in HIV-negative women in all age groups. Among HIV-infected, women, 69% were positive for ≥1 HPV type, 46% for a carcinogenic HPV type, and. 10% for HPV-16. HPV prevalence peaked, at 75% in the HIV-positive women aged. 25-34 years and then declined with age to 37.5% in those ≥55 years old (P trend < .001 ). A significant trend, of higher prevalence of HPV and carcinogenic HPV with lower CD4 ' cell counts and increasing cytologic severity was seen among HIV-positive women. Conclusions. We found a higher prevalence of HPV infection in HIV-positive than in HIV-negative Rwandan women, and the prevalence of HPV and carcinogenic HPV infection decreased with age.

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