Human papillomavirus infection and cervical cytology in HIV-infected and HIV-Uninfected Rwandan women

Diljeet K. Singh, Kathryn Anastos, Donald R. Hoover, Robert D. Burk, Qiuhu Shi, Louis Ngendahayo, Eugene Mutimura, Antonio Cajigas, Venerand Bigirimani, Xiaotao Cai, Janvier Rwamwejo, Magalis Vuolo, Mardge Cohen, Philip E. Castle

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59 Scopus citations

Abstract

Background. Data, on human papillomavirus (HPV) prevalence are essential for developing cost-effective cervical cancer prevention programs. Methods. In 2005,710 human immunodeficiency virus (HlV)-positive and. 226 HIV-negative Rwandan women enrolled in an observational prospective cohort study. Sociodemographic data, CD4 ' cell counts, and cervical specimens were obtained. Cervicovaginal lavage specimens were collected, from each woman and tested, for >40 HPV types by a polymerase chain reaction assay; HPV types 16,18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68 were considered primary carcinogenic HPV types. Results. The prevalence of HPV was higher in HIV-positive women than in HIV-negative women in all age groups. Among HIV-infected, women, 69% were positive for ≥1 HPV type, 46% for a carcinogenic HPV type, and. 10% for HPV-16. HPV prevalence peaked, at 75% in the HIV-positive women aged. 25-34 years and then declined with age to 37.5% in those ≥55 years old (P trend < .001 ). A significant trend, of higher prevalence of HPV and carcinogenic HPV with lower CD4 ' cell counts and increasing cytologic severity was seen among HIV-positive women. Conclusions. We found a higher prevalence of HPV infection in HIV-positive than in HIV-negative Rwandan women, and the prevalence of HPV and carcinogenic HPV infection decreased with age.

Original languageEnglish (US)
Pages (from-to)1851-1861
Number of pages11
JournalJournal of Infectious Diseases
Volume199
Issue number12
DOIs
StatePublished - Jun 5 2009

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Singh, D. K., Anastos, K., Hoover, D. R., Burk, R. D., Shi, Q., Ngendahayo, L., Mutimura, E., Cajigas, A., Bigirimani, V., Cai, X., Rwamwejo, J., Vuolo, M., Cohen, M., & Castle, P. E. (2009). Human papillomavirus infection and cervical cytology in HIV-infected and HIV-Uninfected Rwandan women. Journal of Infectious Diseases, 199(12), 1851-1861. https://doi.org/10.1086/599123