TY - JOUR
T1 - Human papillomavirus infection and cervical cytology in HIV-infected and HIV-Uninfected Rwandan women
AU - Singh, Diljeet K.
AU - Anastos, Kathryn
AU - Hoover, Donald R.
AU - Burk, Robert D.
AU - Shi, Qiuhu
AU - Ngendahayo, Louis
AU - Mutimura, Eugene
AU - Cajigas, Antonio
AU - Bigirimani, Venerand
AU - Cai, Xiaotao
AU - Rwamwejo, Janvier
AU - Vuolo, Magalis
AU - Cohen, Mardge
AU - Castle, Philip E.
N1 - Funding Information:
Financial support: National Institute of Allergy and Infectious Diseases (NIAID) and National Cancer Institute (NCI) (supplements to Bronx/Manhattan Women’s Interagency HIV Study, funded by NIAID [grant UO1-AI-35004]); Center for AIDS Research, Albert Einstein College of Medicine and Montefiore Medical Center (funded by National Institutes of Health [grant NIH AI-51519] and by National Institute of Diabetes and Digestive and Kidney Disease [grant DK54615]); NCI intramural research program.
PY - 2009/6/5
Y1 - 2009/6/5
N2 - Background. Data, on human papillomavirus (HPV) prevalence are essential for developing cost-effective cervical cancer prevention programs. Methods. In 2005,710 human immunodeficiency virus (HlV)-positive and. 226 HIV-negative Rwandan women enrolled in an observational prospective cohort study. Sociodemographic data, CD4 ' cell counts, and cervical specimens were obtained. Cervicovaginal lavage specimens were collected, from each woman and tested, for >40 HPV types by a polymerase chain reaction assay; HPV types 16,18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68 were considered primary carcinogenic HPV types. Results. The prevalence of HPV was higher in HIV-positive women than in HIV-negative women in all age groups. Among HIV-infected, women, 69% were positive for ≥1 HPV type, 46% for a carcinogenic HPV type, and. 10% for HPV-16. HPV prevalence peaked, at 75% in the HIV-positive women aged. 25-34 years and then declined with age to 37.5% in those ≥55 years old (P trend < .001 ). A significant trend, of higher prevalence of HPV and carcinogenic HPV with lower CD4 ' cell counts and increasing cytologic severity was seen among HIV-positive women. Conclusions. We found a higher prevalence of HPV infection in HIV-positive than in HIV-negative Rwandan women, and the prevalence of HPV and carcinogenic HPV infection decreased with age.
AB - Background. Data, on human papillomavirus (HPV) prevalence are essential for developing cost-effective cervical cancer prevention programs. Methods. In 2005,710 human immunodeficiency virus (HlV)-positive and. 226 HIV-negative Rwandan women enrolled in an observational prospective cohort study. Sociodemographic data, CD4 ' cell counts, and cervical specimens were obtained. Cervicovaginal lavage specimens were collected, from each woman and tested, for >40 HPV types by a polymerase chain reaction assay; HPV types 16,18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68 were considered primary carcinogenic HPV types. Results. The prevalence of HPV was higher in HIV-positive women than in HIV-negative women in all age groups. Among HIV-infected, women, 69% were positive for ≥1 HPV type, 46% for a carcinogenic HPV type, and. 10% for HPV-16. HPV prevalence peaked, at 75% in the HIV-positive women aged. 25-34 years and then declined with age to 37.5% in those ≥55 years old (P trend < .001 ). A significant trend, of higher prevalence of HPV and carcinogenic HPV with lower CD4 ' cell counts and increasing cytologic severity was seen among HIV-positive women. Conclusions. We found a higher prevalence of HPV infection in HIV-positive than in HIV-negative Rwandan women, and the prevalence of HPV and carcinogenic HPV infection decreased with age.
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U2 - 10.1086/599123
DO - 10.1086/599123
M3 - Article
C2 - 19435429
AN - SCOPUS:67650458435
SN - 0022-1899
VL - 199
SP - 1851
EP - 1861
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 12
ER -
