Abstract
Amongst the human papillomaviruses (HPVs), the genus Alphapapillomavirus contains HPV types that are uniquely pathogenic. They can be classified into species and types based on genetic distances between viral genomes. Current circulating infectious HPVs constitute a set of viral genomes that have evolved with the rapid expansion of the human population. Viral variants were initially identified through restriction enzyme polymorphisms and more recently through sequence determination of viral fragments. Using partial sequence information, the history of variants, and the association of HPV variants with disease will be discussed with the main focus on the recent utilization of full genome sequence information for variant analyses. The use of multiple sequence alignments of complete viral genomes and phylogenetic analyses have begun to define variant lineages and sublineages using empirically defined differences of 1.0-10.0% and 0.5-1.0%, respectively. These studies provide the basis to define the genetics of HPV pathogenesis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 232-243 |
| Number of pages | 12 |
| Journal | Virology |
| Volume | 445 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Oct 2013 |
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Keywords
- Alphapapillomaviruses
- HPV
- HPV evolution
- HPV variant lineages
- Human papillomavirus variants
ASJC Scopus subject areas
- Virology
Cite this
Human papillomavirus genome variants. / Burk, Robert D.; Harari, Ariana; Chen, Zigui.
In: Virology, Vol. 445, No. 1-2, 10.2013, p. 232-243.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Human papillomavirus genome variants
AU - Burk, Robert D.
AU - Harari, Ariana
AU - Chen, Zigui
PY - 2013/10
Y1 - 2013/10
N2 - Amongst the human papillomaviruses (HPVs), the genus Alphapapillomavirus contains HPV types that are uniquely pathogenic. They can be classified into species and types based on genetic distances between viral genomes. Current circulating infectious HPVs constitute a set of viral genomes that have evolved with the rapid expansion of the human population. Viral variants were initially identified through restriction enzyme polymorphisms and more recently through sequence determination of viral fragments. Using partial sequence information, the history of variants, and the association of HPV variants with disease will be discussed with the main focus on the recent utilization of full genome sequence information for variant analyses. The use of multiple sequence alignments of complete viral genomes and phylogenetic analyses have begun to define variant lineages and sublineages using empirically defined differences of 1.0-10.0% and 0.5-1.0%, respectively. These studies provide the basis to define the genetics of HPV pathogenesis.
AB - Amongst the human papillomaviruses (HPVs), the genus Alphapapillomavirus contains HPV types that are uniquely pathogenic. They can be classified into species and types based on genetic distances between viral genomes. Current circulating infectious HPVs constitute a set of viral genomes that have evolved with the rapid expansion of the human population. Viral variants were initially identified through restriction enzyme polymorphisms and more recently through sequence determination of viral fragments. Using partial sequence information, the history of variants, and the association of HPV variants with disease will be discussed with the main focus on the recent utilization of full genome sequence information for variant analyses. The use of multiple sequence alignments of complete viral genomes and phylogenetic analyses have begun to define variant lineages and sublineages using empirically defined differences of 1.0-10.0% and 0.5-1.0%, respectively. These studies provide the basis to define the genetics of HPV pathogenesis.
KW - Alphapapillomaviruses
KW - HPV
KW - HPV evolution
KW - HPV variant lineages
KW - Human papillomavirus variants
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UR - http://www.scopus.com/inward/citedby.url?scp=84884355784&partnerID=8YFLogxK
U2 - 10.1016/j.virol.2013.07.018
DO - 10.1016/j.virol.2013.07.018
M3 - Article
VL - 445
SP - 232
EP - 243
JO - Virology
JF - Virology
SN - 0042-6822
IS - 1-2
ER -