Human papillomavirus genome variants

Robert D. Burk, Ariana Harari, Zigui Chen

Research output: Contribution to journalArticle

167 Citations (Scopus)

Abstract

Amongst the human papillomaviruses (HPVs), the genus Alphapapillomavirus contains HPV types that are uniquely pathogenic. They can be classified into species and types based on genetic distances between viral genomes. Current circulating infectious HPVs constitute a set of viral genomes that have evolved with the rapid expansion of the human population. Viral variants were initially identified through restriction enzyme polymorphisms and more recently through sequence determination of viral fragments. Using partial sequence information, the history of variants, and the association of HPV variants with disease will be discussed with the main focus on the recent utilization of full genome sequence information for variant analyses. The use of multiple sequence alignments of complete viral genomes and phylogenetic analyses have begun to define variant lineages and sublineages using empirically defined differences of 1.0-10.0% and 0.5-1.0%, respectively. These studies provide the basis to define the genetics of HPV pathogenesis.

Original languageEnglish (US)
Pages (from-to)232-243
Number of pages12
JournalVirology
Volume445
Issue number1-2
DOIs
StatePublished - Oct 2013

Fingerprint

Human Genome
Viral Genome
Alphapapillomavirus
Sequence Alignment
Medical Genetics
Sequence Analysis
History
Genome
Enzymes
Population

Keywords

  • Alphapapillomaviruses
  • HPV
  • HPV evolution
  • HPV variant lineages
  • Human papillomavirus variants

ASJC Scopus subject areas

  • Virology

Cite this

Human papillomavirus genome variants. / Burk, Robert D.; Harari, Ariana; Chen, Zigui.

In: Virology, Vol. 445, No. 1-2, 10.2013, p. 232-243.

Research output: Contribution to journalArticle

Burk, RD, Harari, A & Chen, Z 2013, 'Human papillomavirus genome variants', Virology, vol. 445, no. 1-2, pp. 232-243. https://doi.org/10.1016/j.virol.2013.07.018
Burk, Robert D. ; Harari, Ariana ; Chen, Zigui. / Human papillomavirus genome variants. In: Virology. 2013 ; Vol. 445, No. 1-2. pp. 232-243.
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