Human papillomavirus DNA remains detectable longer than related cervical cytologic abnormalities

Mark Schiffman, Cosette M. Wheeler, Philip E. Castle

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Cervical human papillomavirus (HPV) infections are at high risk of neoplastic progression if they persist. Persistence can be measured by repeated HPV DNA tests or by cytologic testing. Thus, it is useful to understand the relationship between these 2 measurements. To explore the relative timing of HPV DNA clearance versus cytologic regression, data were analyzed from 840 study participants who were followed-up by repeat thin-layer cytology and HPV testing by a hybrid capture test at 6-month intervals for 2 years. On average, HPV DNA detection persisted longer than related cytologic abnormalities (P<.001). HPV type-specific data from a subset of 448 women with complete polymerase chain reaction test data confirmed that HPV DNA persisted longer than cytologic abnormalities (P<.001). It appears that the natural history of HPV typically includes periods before and after cytologic abnormality, in which HPV DNA is the more sensitive indicator of infection.

Original languageEnglish (US)
Pages (from-to)1169-1172
Number of pages4
JournalJournal of Infectious Diseases
Volume186
Issue number8
DOIs
StatePublished - Oct 15 2002
Externally publishedYes

Fingerprint

DNA
Human Papillomavirus DNA Tests
Papillomavirus Infections
Natural History
Cell Biology
Polymerase Chain Reaction
Infection

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Human papillomavirus DNA remains detectable longer than related cervical cytologic abnormalities. / Schiffman, Mark; Wheeler, Cosette M.; Castle, Philip E.

In: Journal of Infectious Diseases, Vol. 186, No. 8, 15.10.2002, p. 1169-1172.

Research output: Contribution to journalArticle

@article{716f32bb3b834a2fafc102e67ba216e1,
title = "Human papillomavirus DNA remains detectable longer than related cervical cytologic abnormalities",
abstract = "Cervical human papillomavirus (HPV) infections are at high risk of neoplastic progression if they persist. Persistence can be measured by repeated HPV DNA tests or by cytologic testing. Thus, it is useful to understand the relationship between these 2 measurements. To explore the relative timing of HPV DNA clearance versus cytologic regression, data were analyzed from 840 study participants who were followed-up by repeat thin-layer cytology and HPV testing by a hybrid capture test at 6-month intervals for 2 years. On average, HPV DNA detection persisted longer than related cytologic abnormalities (P<.001). HPV type-specific data from a subset of 448 women with complete polymerase chain reaction test data confirmed that HPV DNA persisted longer than cytologic abnormalities (P<.001). It appears that the natural history of HPV typically includes periods before and after cytologic abnormality, in which HPV DNA is the more sensitive indicator of infection.",
author = "Mark Schiffman and Wheeler, {Cosette M.} and Castle, {Philip E.}",
year = "2002",
month = "10",
day = "15",
doi = "10.1086/343816",
language = "English (US)",
volume = "186",
pages = "1169--1172",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "8",

}

TY - JOUR

T1 - Human papillomavirus DNA remains detectable longer than related cervical cytologic abnormalities

AU - Schiffman, Mark

AU - Wheeler, Cosette M.

AU - Castle, Philip E.

PY - 2002/10/15

Y1 - 2002/10/15

N2 - Cervical human papillomavirus (HPV) infections are at high risk of neoplastic progression if they persist. Persistence can be measured by repeated HPV DNA tests or by cytologic testing. Thus, it is useful to understand the relationship between these 2 measurements. To explore the relative timing of HPV DNA clearance versus cytologic regression, data were analyzed from 840 study participants who were followed-up by repeat thin-layer cytology and HPV testing by a hybrid capture test at 6-month intervals for 2 years. On average, HPV DNA detection persisted longer than related cytologic abnormalities (P<.001). HPV type-specific data from a subset of 448 women with complete polymerase chain reaction test data confirmed that HPV DNA persisted longer than cytologic abnormalities (P<.001). It appears that the natural history of HPV typically includes periods before and after cytologic abnormality, in which HPV DNA is the more sensitive indicator of infection.

AB - Cervical human papillomavirus (HPV) infections are at high risk of neoplastic progression if they persist. Persistence can be measured by repeated HPV DNA tests or by cytologic testing. Thus, it is useful to understand the relationship between these 2 measurements. To explore the relative timing of HPV DNA clearance versus cytologic regression, data were analyzed from 840 study participants who were followed-up by repeat thin-layer cytology and HPV testing by a hybrid capture test at 6-month intervals for 2 years. On average, HPV DNA detection persisted longer than related cytologic abnormalities (P<.001). HPV type-specific data from a subset of 448 women with complete polymerase chain reaction test data confirmed that HPV DNA persisted longer than cytologic abnormalities (P<.001). It appears that the natural history of HPV typically includes periods before and after cytologic abnormality, in which HPV DNA is the more sensitive indicator of infection.

UR - http://www.scopus.com/inward/record.url?scp=0037108660&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037108660&partnerID=8YFLogxK

U2 - 10.1086/343816

DO - 10.1086/343816

M3 - Article

C2 - 12355370

AN - SCOPUS:0037108660

VL - 186

SP - 1169

EP - 1172

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 8

ER -