Human papillomavirus and cervical neoplasia

Mark H. Einstein, Gary L. Goldberg

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Cervical cancer accounts for about 10% of all newly diagnosed cancers in women worldwide. The association between HPV infection and cervical neoplasia appears to be stronger than the association between smoking and lung cancer. At least 20 oncogenic HPV types have been identified in > 95% of preinvasive and invasive cervical cancers, HPV type 16 being the most common. HPV detection is important to identify those patients who may be at high risk for the development of cervical neoplasia. Detection techniques include Hybrid Capture (Digene, Silver Springs, MD) and PCR. Viral integration appears to be one of the necessary steps in malignant transformation. Recently, some of the repeated chromosomal alterations and patterns of integration sites have been identified in cervical cancer specimens. The low rate of HPV-negative cancers implies an effective HPV vaccine might have the ability to eradicate cervical cancer worldwide.

Original languageEnglish (US)
Pages (from-to)1080-1085
Number of pages6
JournalCancer Investigation
Volume20
Issue number7-8
DOIs
StatePublished - 2002

Fingerprint

Uterine Cervical Neoplasms
Neoplasms
Virus Integration
Papillomavirus Vaccines
Aptitude
Human papillomavirus 16
Silver
Lung Neoplasms
Smoking
Polymerase Chain Reaction
Infection

Keywords

  • Cervical cancer
  • Cervical neoplasia
  • Human papillomavirus

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Einstein, M. H., & Goldberg, G. L. (2002). Human papillomavirus and cervical neoplasia. Cancer Investigation, 20(7-8), 1080-1085. https://doi.org/10.1081/CNV-120005927

Human papillomavirus and cervical neoplasia. / Einstein, Mark H.; Goldberg, Gary L.

In: Cancer Investigation, Vol. 20, No. 7-8, 2002, p. 1080-1085.

Research output: Contribution to journalArticle

Einstein, MH & Goldberg, GL 2002, 'Human papillomavirus and cervical neoplasia', Cancer Investigation, vol. 20, no. 7-8, pp. 1080-1085. https://doi.org/10.1081/CNV-120005927
Einstein, Mark H. ; Goldberg, Gary L. / Human papillomavirus and cervical neoplasia. In: Cancer Investigation. 2002 ; Vol. 20, No. 7-8. pp. 1080-1085.
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