Human papillomavirus 6/11 and 16/18 in Schneiderian inverted papillomas. In situ hybridization with human papillomavirus RNA probes

M. Brandwein, B. Steinberg, S. Thung, H. Biller, Teresa P. DiLorenzo, R. Galli

Research output: Contribution to journalArticle

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Abstract

Schneiderian inverted papillomas may be troublesome lesions for clinicians with propensity for recurrences. Dysplasia is not uncommonly seen, and some of these lesions do progress to develop squamous carcinoma. The auhors hybridized in situ seven inverted papillomas with RNA probes to human papillomavirus (HPV) 6, 11, 16, and 18. Four of these contained dysplasia, two were without dysplasia, and one contained invasive squamous cell carcinoma. Five inverted papillomas showed evidence of HPV infection based on hybridization. One with mild to moderate and one with severe dysplasia, and one without dysplasia hybridized with mixed probe HPV 6/11. One with mild dysplasia and one associated with invasive squamous cell carcinoma hybridized with mixed probe HPV 16/18. One inverted papilloma without dysplasia and one with severe dysplasia did not definitively hybridize with either mixed probe. These findings raise interesting questions as to role of HPV 6/11 and 16/18 in the development of inverted papillomas, and probably on the progression to an carcinoma.

Original languageEnglish (US)
Pages (from-to)1708-1713
Number of pages6
JournalCancer
Volume63
Issue number9
StatePublished - 1989

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Inverted Papilloma
Human papillomavirus 11
Human papillomavirus 6
RNA Probes
Human papillomavirus 16
In Situ Hybridization
Squamous Cell Carcinoma
Human papillomavirus 18
Papillomavirus Infections
Carcinoma
Recurrence

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Human papillomavirus 6/11 and 16/18 in Schneiderian inverted papillomas. In situ hybridization with human papillomavirus RNA probes. / Brandwein, M.; Steinberg, B.; Thung, S.; Biller, H.; DiLorenzo, Teresa P.; Galli, R.

In: Cancer, Vol. 63, No. 9, 1989, p. 1708-1713.

Research output: Contribution to journalArticle

Brandwein, M. ; Steinberg, B. ; Thung, S. ; Biller, H. ; DiLorenzo, Teresa P. ; Galli, R. / Human papillomavirus 6/11 and 16/18 in Schneiderian inverted papillomas. In situ hybridization with human papillomavirus RNA probes. In: Cancer. 1989 ; Vol. 63, No. 9. pp. 1708-1713.
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AU - DiLorenzo, Teresa P.

AU - Galli, R.

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