@article{878b7f93261f49928eedfa8aed79fb1c,
title = "Human papillomavirus 33 worldwide genetic variation and associated risk of cervical cancer",
abstract = "Human papillomavirus (HPV) 33, a member of the HPV16-related alpha-9 species group, is found in approximately 5% of cervical cancers worldwide. The current study aimed to characterize the genetic diversity of HPV33 and to explore the association of HPV33 variants with the risk for cervical cancer. Taking advantage of the International Agency for Research on Cancer biobank, we sequenced the entire E6 and E7 open reading frames of 213 HPV33-positive cervical samples from 30 countries. We identified 28 HPV33 variants that formed 5 phylogenetic groups: the previously identified A1, A2, and B (sub)lineages and the novel A3 and C (sub)lineages. The A1 sublineage was strongly over-represented in cervical cases compared to controls in both Africa and Europe. In conclusion, we provide a classification system for HPV33 variants based on the sequence of E6 and E7 and suggest that the association of HPV33 with cervical cancer may differ by variant (sub)lineage.",
keywords = "Cervical cancer, HPV, Phylogeny, Variants",
author = "Chen, {Alyce A.} and Heideman, {Dani{\"e}lle A.M.} and Debby Boon and Zigui Chen and Burk, {Robert D.} and {De Vuyst}, Hugo and Tarik Gheit and Snijders, {Peter J.F.} and Massimo Tommasino and Silvia Franceschi and Clifford, {Gary M.}",
note = "Funding Information: This work was supported by grants from the Association for International Cancer Research, United Kingdom (project grant 08-0213), the Institut National du Cancer, France (collaboration agreement 07/ 3D1514/PL-89-05/NG-LC), and the Fondation Innovations en Infectiologie (FINOVI) (project AO1-project 2). The work of AAC was undertaken during the tenure of a Postdoctoral Fellowship from the International Agency for Research on Cancer, partially supported by the European Commission FP7 Marie Curie Actions – People – Co-funding of regional, national and international programmes (COFUND). The work of RDB and ZC was supported in part by the National Cancer Institute ( CA78527 ), the Einstein-Montefiore Center for AIDS funded by the NIH ( AI-51519 ), and the Einstein Cancer Research Center ( P30CA013330 ) by the National Cancer Institute . The authors have no conflict of interest to declare. The authors would like to thank Vanessa Tenet and Jerome Vignat for technical assistance. The members of the HPV Variant Study Group include the previous IARC staff (N. Mu{\v n}oz, R. Herrero, X. Bosch) and local study coordinators in the following countries: Algeria (D. Hammouda), Argentina (D. Loria, E. Matos), Bhutan (U. Tshomo, Dorji), Brazil (J. Eluf-Neto), Chile (C. Ferreccio, J. M. Ojeda), China (M. Dai, L.K. Li, R. F. Wu), Fiji (N. Pearce), Georgia (T.Alibegashvili, D. Kordzaia), Guinea (N. Keita, M. Koulibaly), India (T. Rajkumar, R. Rajkumar), Italy (M. Sideri), Kenya (P. Gichangi), South Korea (D.-H. Lee, H. R. Shin), Mali (S. Bayo), Mongolia (B. Dondog), Morocco (N. Chaouki), Nepal (A. T. L. Sherpa), Nigeria (J. O. Thomas, C. Okolo, I. Adewole), Pakistan (S. A. Raza), Panama (E. de los Rios), Paraguay (P. A. Rolon), Peru (E. Caceres, C. Santos), Poland (W. Zatonski), Senegal (C. S. Boye, C. Toure-Kane, E. S. Mbaye, H. Diop-Ndiaye), South Africa (D. Moodley), Spain (S. de Sanjose, X. Castellsague), Tanzania (J. N. Kitinya), Thailand (S. Chichareon, S. Sukvirach, S. Tunsakul), Uganda (H. R. Wabinga), Vanuatu (B. Aruhuri, I.H. Frazer), and Vietnam (P. T. H. Anh, N. T. Hieu). ",
year = "2014",
month = jan,
day = "5",
doi = "10.1016/j.virol.2013.10.033",
language = "English (US)",
volume = "448",
pages = "356--362",
journal = "Virology",
issn = "0042-6822",
publisher = "Academic Press Inc.",
}