Human microbial metabolite mimicry as a strategy to expand the chemical space of potential drugs

Hao Li, Harmit S. Ranhotra, Sridhar Mani, Zdeněk Dvořák, Harry Sokol, Rolf Müller

Research output: Contribution to journalShort survey

Abstract

The concept of small-molecule mimicry even of weak microbial metabolites present in rodents and humans, as a means to expand drug repertoires, is new. Hitherto, there are few proof-of-concept papers demonstrating utility of this concept. More recently, papers demonstrating mimicry of intestinal microbial metabolites could expand the drug repertoire for diseases such as inflammatory bowel disease (IBD). We opine that, as more functional metabolite–receptor pairings are discovered, small-molecule metabolite mimicry could be a significant effort in drug discovery.

Original languageEnglish (US)
JournalDrug Discovery Today
DOIs
StateAccepted/In press - 2020

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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