Human Immunodeficiency Virus Type 1 Infection in Homosexual Men Who Remain Seronegative for Prolonged Periods

Celso Bianco, Joan Uehlinger, Harold S. Kalpan, Fernando Aiuti, Fabrizio Ensoli, Valeria Fiorelli, C. Robert Horsburgh, Chin Yih ou, Scott D. Holmberg, Gerald Schochetman, Harold W. Jaffe, Alan R. Lifson, George W. Rutherford, li Zhen Pan, Rachel Royce, Warren Winkelstein, Jay A. Levy, Thomas F. Zuck, David T. Imagawa, Moon H. LeeBarbara Visscher, Janice Dudley, Roger Detels

Research output: Contribution to journalLetter

3 Scopus citations

Abstract

To the Editor: Imagawa et al. (June 1 issue)1 reported that some persons infected with human immunodeficiency virus type 1 (HIV-1) may remain seronegative for prolonged periods. Haseltine,2 in an accompanying editorial, reviewed regulatory viral genes that may explain silent HIV-1 infections. The authors of both articles commented on the potential relevance of these findings to the safety of the blood supply. Unfortunately, they did not provide data addressing the differences between the criteria used in their epidemiologic study and well-established procedures currently applied in screening blood donors. For instance, the authors considered as negative all samples that were reactive….

Original languageEnglish (US)
Pages (from-to)1678-1681
Number of pages4
JournalNew England Journal of Medicine
Volume321
Issue number24
DOIs
StatePublished - Dec 14 1989
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Bianco, C., Uehlinger, J., Kalpan, H. S., Aiuti, F., Ensoli, F., Fiorelli, V., Horsburgh, C. R., ou, C. Y., Holmberg, S. D., Schochetman, G., Jaffe, H. W., Lifson, A. R., Rutherford, G. W., Pan, L. Z., Royce, R., Winkelstein, W., Levy, J. A., Zuck, T. F., Imagawa, D. T., ... Detels, R. (1989). Human Immunodeficiency Virus Type 1 Infection in Homosexual Men Who Remain Seronegative for Prolonged Periods. New England Journal of Medicine, 321(24), 1678-1681. https://doi.org/10.1056/NEJM198912143212412