Human Immunodeficiency Virus (HIV) Circulating Immune Complexes in Infected Children

Maadhava Ellaurie, Theresa A. Calvelli, Arye Rubinstein

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Circulating immune complexes (CIC) were studied for the presence of human immunodeficiency virus (HIV) antigens (HIV-Ag) in 55 children infected by the human immunodeficiency virus type 1 (HIV-1). CIC were elevated in 85% of patients. In 33 of 55 patients CIC included at least one HIV-Ag (HIV-Ag-CIC). Sixty percent of patients had p17 antigen, 50% had p24 antigen, and 16% had gp120 associated with CIC. Levels of HIV-Ag-CIC did not correlate with free serum HIV antigens. Patients with high HIV-Ag-CIC had a more severe clinical course and 90% of those with markedly elevated HIV-Ag-CIC (> 3 +) have died within 6 to 24 months. HIV-Ag-CIC were also present in some patients including neonates and young infants in whom free HIV-Ag was undetectable. Monitoring of HIV-Ag in isolated CIC may be of value for early detection of HIV infection and for monitoring of disease outcome.

Original languageEnglish (US)
Pages (from-to)1437-1441
Number of pages5
JournalAIDS Research and Human Retroviruses
Volume6
Issue number12
DOIs
StatePublished - Dec 1990

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

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