Human immunodeficiency virus (HIV) circulating immune complexes in infected children

M. Ellaurie, T. A. Calvelli, Arye Rubinstein

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Circulating immune complexes (CIC) were studied for the presence of human immunodeficiency virus (HIV) antigens (HIV-Ag) in 55 children infected by the human immunodeficiency virus type 1 (HIV-1). CIC were elevated in 85% of patients. In 33 of 55 patients CIC included at least one HIV-Ag (HIV-Ag-CIC). Sixty percent of patients had p17 antigen, 50% had p24 antigen, and 16% had gp120 associated with CIC. Levels of HIV-Ag-CIC did not correlate with free serum HIV antigens. Patients with high HIV-Ag-CIC had a more severe clinical course and 90% of those with markedly elevated HIV-Ag-CIC (> 3+) have died within 6 to 24 months. HIV-Ag-CIC were also present in some patients including neonates and young infants in whom free HIV-Ag was undetectable. Monitoring of HIV-Ag in isolated CIC may be of value for early detection of HIV infection and for monitoring of disease outcome.

Original languageEnglish (US)
Pages (from-to)1437-1441
Number of pages5
JournalAIDS Research and Human Retroviruses
Volume6
Issue number12
StatePublished - 1990

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Antigen-Antibody Complex
HIV
Antigens
Virus Diseases
HIV-1
Newborn Infant

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Human immunodeficiency virus (HIV) circulating immune complexes in infected children. / Ellaurie, M.; Calvelli, T. A.; Rubinstein, Arye.

In: AIDS Research and Human Retroviruses, Vol. 6, No. 12, 1990, p. 1437-1441.

Research output: Contribution to journalArticle

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