Human homeo box-containing genes located at chromosome regions 2q31→2q37 and 12q12→12q13

L. A. Cannizzaro, C. M. Croce, C. A. Griffin, A. Simeone, E. Boncinelli, K. Huebner

Research output: Contribution to journalArticle

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Abstract

Four human homeo box-containing cDNAs isolated from mRNA of an SV40-transformed human fibroblast cell line have been regionally localized on the human gene map. One cDNA clone, c10, was found to be nearly identical to the previously mapped Hox-2.1 gene at 17q21. A second cDNA clone, c1, which is 87% homologous to Hox-2.2 at the nucleotide level but is distinct from Hox-2.1 and Hox-2.2, also maps to this region of human chromosome 17 and is probably another member of the Hox-2 cluster of homeo box-containing genes. The third cDNA clone, c8, in which the homeo box is ~84% homologous to the mouse Hox-1.1 homeo box region on mouse chromosome 6, maps to chromosome region 12q12→12q13, a region that is involved in chromosome abnormalities in human seminomas and teratomas. The fourth cDNA clone, c13, whose homeo box is ~73% homologous to the Hox-2.2 homeo box sequence, is located at chromosome region 2q31→q37. The human homeo box-containing cluster of genes at chromosome region 17q21 is the human cognate of the mouse homeo box-containing gene cluster on mouse chromosome 11. Other mouse homeo box-containing genes of the Antennapedia class (class I) map to mouse chromosomes 6 (Hox-1, proximal to the IgK locus) and 15 (Hox-3). A mouse gene, En-1, with an engrailed-like homeo box (class II) and flanking region maps to mouse chromosome 1 (near the dominant hemimelia gene). Neither of the class I homeo box-containing genes - c8 and c13 - maps to a region of obvious homology to chromosomal positions of the presently known mouse homeo box containing genes.

Original languageEnglish (US)
Pages (from-to)1-15
Number of pages15
JournalAmerican Journal of Human Genetics
Volume41
Issue number1
StatePublished - 1987
Externally publishedYes

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Homeobox Genes
Chromosomes
Complementary DNA
Clone Cells
Chromosomes, Human, Pair 6
Multigene Family
Ectromelia
MHC Class I Genes
Dominant Genes
Seminoma
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 1
Teratoma
Human Chromosomes
Chromosome Aberrations
Genes
Nucleotides
Fibroblasts

ASJC Scopus subject areas

  • Genetics

Cite this

Cannizzaro, L. A., Croce, C. M., Griffin, C. A., Simeone, A., Boncinelli, E., & Huebner, K. (1987). Human homeo box-containing genes located at chromosome regions 2q31→2q37 and 12q12→12q13. American Journal of Human Genetics, 41(1), 1-15.

Human homeo box-containing genes located at chromosome regions 2q31→2q37 and 12q12→12q13. / Cannizzaro, L. A.; Croce, C. M.; Griffin, C. A.; Simeone, A.; Boncinelli, E.; Huebner, K.

In: American Journal of Human Genetics, Vol. 41, No. 1, 1987, p. 1-15.

Research output: Contribution to journalArticle

Cannizzaro, LA, Croce, CM, Griffin, CA, Simeone, A, Boncinelli, E & Huebner, K 1987, 'Human homeo box-containing genes located at chromosome regions 2q31→2q37 and 12q12→12q13', American Journal of Human Genetics, vol. 41, no. 1, pp. 1-15.
Cannizzaro LA, Croce CM, Griffin CA, Simeone A, Boncinelli E, Huebner K. Human homeo box-containing genes located at chromosome regions 2q31→2q37 and 12q12→12q13. American Journal of Human Genetics. 1987;41(1):1-15.
Cannizzaro, L. A. ; Croce, C. M. ; Griffin, C. A. ; Simeone, A. ; Boncinelli, E. ; Huebner, K. / Human homeo box-containing genes located at chromosome regions 2q31→2q37 and 12q12→12q13. In: American Journal of Human Genetics. 1987 ; Vol. 41, No. 1. pp. 1-15.
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abstract = "Four human homeo box-containing cDNAs isolated from mRNA of an SV40-transformed human fibroblast cell line have been regionally localized on the human gene map. One cDNA clone, c10, was found to be nearly identical to the previously mapped Hox-2.1 gene at 17q21. A second cDNA clone, c1, which is 87{\%} homologous to Hox-2.2 at the nucleotide level but is distinct from Hox-2.1 and Hox-2.2, also maps to this region of human chromosome 17 and is probably another member of the Hox-2 cluster of homeo box-containing genes. The third cDNA clone, c8, in which the homeo box is ~84{\%} homologous to the mouse Hox-1.1 homeo box region on mouse chromosome 6, maps to chromosome region 12q12→12q13, a region that is involved in chromosome abnormalities in human seminomas and teratomas. The fourth cDNA clone, c13, whose homeo box is ~73{\%} homologous to the Hox-2.2 homeo box sequence, is located at chromosome region 2q31→q37. The human homeo box-containing cluster of genes at chromosome region 17q21 is the human cognate of the mouse homeo box-containing gene cluster on mouse chromosome 11. Other mouse homeo box-containing genes of the Antennapedia class (class I) map to mouse chromosomes 6 (Hox-1, proximal to the IgK locus) and 15 (Hox-3). A mouse gene, En-1, with an engrailed-like homeo box (class II) and flanking region maps to mouse chromosome 1 (near the dominant hemimelia gene). Neither of the class I homeo box-containing genes - c8 and c13 - maps to a region of obvious homology to chromosomal positions of the presently known mouse homeo box containing genes.",
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